Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation

Melissa A. Brotman, Layla Kassem, Michelle M. Reising, Amanda E. Guyer, Daniel P. Dickstein, Brendan A. Rich, Kenneth E. Towbin, Daniel S. Pine, Francis J. McMahon, Ellen Leibenluft

Research output: Contribution to journalArticle

Abstract

Objective: Controversy exists regarding whether nonepisodic irritability and hyperarousal (severe mood dysregulation) is a phenotype of pediatric bipolar disorder. The authors compared axis I diagnoses in parents of children with narrow phenotype bipolar disorder and parents of youth with severe mood dysregulation. Method: Parents of youth with narrow phenotype bipolar disorder (proband N=33, parent N=42) and youth with severe mood dysregulation (proband N=30, parent N=37) were interviewed by clinicians who were blind to the child's diagnostic status using the Diagnostic Interview for Genetic Studies. Results: Compared to parents of youth with severe mood dysregulation, parents of youth with narrow phenotype bipolar disorder were significantly more likely to be diagnosed with bipolar disorder. There were no other diagnostic differences between the two groups. Conclusions: These data suggest that narrow phenotype bipolar disorder may be distinct from severe mood dysregulation in terms of familial aggregation. Additionally, the familiality of narrow phenotype bipolar disorder and adult DSM-IV bipolar disorder is high.

Original languageEnglish (US)
Pages (from-to)1238-1241
Number of pages4
JournalAmerican Journal of Psychiatry
Volume164
Issue number8
DOIs
StatePublished - Aug 2007
Externally publishedYes

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Bipolar Disorder
Phenotype
Parents
Diagnostic and Statistical Manual of Mental Disorders
Interviews
Pediatrics

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Brotman, M. A., Kassem, L., Reising, M. M., Guyer, A. E., Dickstein, D. P., Rich, B. A., ... Leibenluft, E. (2007). Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation. American Journal of Psychiatry, 164(8), 1238-1241. https://doi.org/10.1176/appi.ajp.2007.06101619

Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation. / Brotman, Melissa A.; Kassem, Layla; Reising, Michelle M.; Guyer, Amanda E.; Dickstein, Daniel P.; Rich, Brendan A.; Towbin, Kenneth E.; Pine, Daniel S.; McMahon, Francis J.; Leibenluft, Ellen.

In: American Journal of Psychiatry, Vol. 164, No. 8, 08.2007, p. 1238-1241.

Research output: Contribution to journalArticle

Brotman, MA, Kassem, L, Reising, MM, Guyer, AE, Dickstein, DP, Rich, BA, Towbin, KE, Pine, DS, McMahon, FJ & Leibenluft, E 2007, 'Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation', American Journal of Psychiatry, vol. 164, no. 8, pp. 1238-1241. https://doi.org/10.1176/appi.ajp.2007.06101619
Brotman, Melissa A. ; Kassem, Layla ; Reising, Michelle M. ; Guyer, Amanda E. ; Dickstein, Daniel P. ; Rich, Brendan A. ; Towbin, Kenneth E. ; Pine, Daniel S. ; McMahon, Francis J. ; Leibenluft, Ellen. / Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation. In: American Journal of Psychiatry. 2007 ; Vol. 164, No. 8. pp. 1238-1241.
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AU - Dickstein, Daniel P.

AU - Rich, Brendan A.

AU - Towbin, Kenneth E.

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