Parent education and biologic factors influence on cognition in sickle cell anemia

Allison A. King, John Strouse, Mark J. Rodeghier, Bruce E. Compas, James F Casella, Robert C. Mckinstry, Michael J. Noetzel, Charles T. Quinn, Rebecca Ichord, Michael M. Dowling, J. Philip Miller, Michael R. Debaun

Research output: Contribution to journalArticle

Abstract

Children with sickle cell anemia have a high prevalence of silent cerebral infarcts (SCIs) that are associated with decreased full-scale intelligence quotient (FSIQ). While the educational attainment of parents is a known strong predictor of the cognitive development of children in general, the role of parental education in sickle cell anemia along with other factors that adversely affect cognitive function (anemia, cerebral infarcts) is not known. We tested the hypothesis that both the presence of SCI and parental education would impact FSIQ in children with sickle cell anemia. A multicenter, cross-sectional study was conducted in 19 US sites of the Silent Infarct Transfusion Trial among children with sickle cell anemia, age 5-15 years. All were screened for SCIs. Participants with and without SCI were administered the Wechsler Abbreviated Scale of Intelligence. A total of 150 participants (107 with and 43 without SCIs) were included in the analysis. In a multivariable linear regression model for FSIQ, the absence of college education for the head of household was associated with a decrease of 6.2 points (P=0.005); presence of SCI with a 5.2 point decrease (P=0.017); each $1000 of family income per capita with a 0.33 point increase (P=0.023); each increase of 1 year in age with a 0.96 point decrease (P=0.023); and each 1% (absolute) decrease in hemoglobin oxygen saturation with 0.75 point decrease (P=0.030). In conclusion, FSIQ in children with sickle cell anemia is best accounted for by a multivariate model that includes both biologic and socioenvironmental factors.

Original languageEnglish (US)
Pages (from-to)162-167
Number of pages6
JournalAmerican Journal of Hematology
Volume89
Issue number2
DOIs
StatePublished - 2014

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Biological Factors
Sickle Cell Anemia
Intelligence
Cognition
Education
Linear Models
Wechsler Scales
Child Development
Anemia
Hemoglobins
Cross-Sectional Studies
Parents
Oxygen

ASJC Scopus subject areas

  • Hematology

Cite this

Parent education and biologic factors influence on cognition in sickle cell anemia. / King, Allison A.; Strouse, John; Rodeghier, Mark J.; Compas, Bruce E.; Casella, James F; Mckinstry, Robert C.; Noetzel, Michael J.; Quinn, Charles T.; Ichord, Rebecca; Dowling, Michael M.; Miller, J. Philip; Debaun, Michael R.

In: American Journal of Hematology, Vol. 89, No. 2, 2014, p. 162-167.

Research output: Contribution to journalArticle

King, AA, Strouse, J, Rodeghier, MJ, Compas, BE, Casella, JF, Mckinstry, RC, Noetzel, MJ, Quinn, CT, Ichord, R, Dowling, MM, Miller, JP & Debaun, MR 2014, 'Parent education and biologic factors influence on cognition in sickle cell anemia', American Journal of Hematology, vol. 89, no. 2, pp. 162-167. https://doi.org/10.1002/ajh.23604
King, Allison A. ; Strouse, John ; Rodeghier, Mark J. ; Compas, Bruce E. ; Casella, James F ; Mckinstry, Robert C. ; Noetzel, Michael J. ; Quinn, Charles T. ; Ichord, Rebecca ; Dowling, Michael M. ; Miller, J. Philip ; Debaun, Michael R. / Parent education and biologic factors influence on cognition in sickle cell anemia. In: American Journal of Hematology. 2014 ; Vol. 89, No. 2. pp. 162-167.
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AU - Noetzel, Michael J.

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AU - Miller, J. Philip

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