Abstract
The effect of surgical parathyroidectomy and/or cyclo-oxygenase inhibition on noradrenaline-induced blood pressure (BP) responses were investigated in a rat model of chronic uraemia. The blood pressure responses to noradrenaline were significantly lower in uraemic rats when compared with the responses of non-ureamic animals. Blood pressure responses of previously parathyroidectomised uraemic rats were significantly greater than sham-operated uraemic rats, as were the responses of uraemic rats pretreated with the cyclo-oxygenase inhibitor, indomethacin. Pretreatment of uraemic rats with both indomethacin and parathyroidectomy improved blood pressure responses to a degree equal to either manoeuvre alone, but did not exhibit an additive effect. These data suggest a role for parathyroid hormone and prostaglandins in the pathogenesis of the diminished noradrenaline responsiveness in uraemia, and suggest a common mechanism.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 83-85 |
| Number of pages | 3 |
| Journal | Nephrology Dialysis Transplantation |
| Volume | 2 |
| Issue number | 2 |
| State | Published - 1987 |
ASJC Scopus subject areas
- Nephrology
- Transplantation