Parathyroid imaging after intraarterial injections of [ 75Se]selenomethionine

J. L. Stock, A. G. Krudy, J. L. Doppman, A. E. Jones, M. F. Brennan, M. F. Attie, R. W. Downs, M. A. Levine, S. J. Marx, A. M. Spiegel, G. D. Aurbach

Research output: Contribution to journalArticlepeer-review

Abstract

Thirteen patients with persistent hyperparathyroidism after unsuccessful neck surgery were given up to 250 μCi [ 75Se]selenomethionine intraarterially during parathyroid arteriography. γ-Camera images of the neck and mediastinum localized abnormal parathyroids in four of five patients receiving complete injections, despite very small glands or unsuccessful arteriograms in some of the patients. Correctly localizing images were obtained in three patients receiving incomplete injections. However, images in five of eight of the remaining patients receiving incomplete injections showed areas of false positive uptake, and there was no way preoperatively to distinguish these from the true positive studies. We conclude that intraarterial injection of radioselenomethionine is a simple supplementary procedure in patients undergoing arteriography that may, with proper technique, be useful in identifying small foci of abnormal parathyroid tissue.

Original languageEnglish (US)
Pages (from-to)835-839
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume52
Issue number5
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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