Abstract
Background: Recent evidence suggests that parathyroid hormone (PTH) has effects on vascular smooth muscle cells, the rennin-angiotensin system and kidney function, but less is known about its role in the development of hypertension. The distribution of serum PTH also varies by race. Methods and results: Therefore, we examined the relation between PTH and incident hypertension and tested for interaction by race among 7504 Atherosclerosis Risk in Communities participants (1264 black, 6240 white, median age 56 years) without initial hypertension in 1990-1992. During a median follow-up of 6 years, 1487 white and 509 black participants developed hypertension. In the overall study population, PTH was not associated with incident hypertension after adjustment for demographics and behavioral risk factors [hazard ratio highest vs. lowest quintiles, 95% confidence interval: 1.11 (0.96-1.28); P for linear trend 0.02]. Although the interaction was not statistically significant (P = 0.60), there was some evidence that the PTH-hypertension association differed by race. Among blacks, PTH was positively associated with incident hypertension, independent of demographics, and behavioral risk factors (P for linear trend 0.003). Among whites, PTH was not associated with hypertension risk. Results were similar when comparing participants with elevated versus nonelevated PTH (≥65 vs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 196-203 |
| Number of pages | 8 |
| Journal | Journal of Hypertension |
| Volume | 34 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2016 |
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Keywords
- Cohort study
- Hypertension
- Parathyroid hormone
- Race disparity
ASJC Scopus subject areas
- Internal Medicine
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Parathyroid hormone and the risk of incident hypertension : The Atherosclerosis Risk in Communities study. / Yao, Lu; Folsom, Aaron R.; Pankow, James S.; Selvin, Elizabeth; Michos, Erin Donnelly; Alonso, Alvaro; Tang, Weihong; Lutsey, Pamela L.
In: Journal of Hypertension, Vol. 34, No. 2, 01.02.2016, p. 196-203.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Parathyroid hormone and the risk of incident hypertension
T2 - The Atherosclerosis Risk in Communities study
AU - Yao, Lu
AU - Folsom, Aaron R.
AU - Pankow, James S.
AU - Selvin, Elizabeth
AU - Michos, Erin Donnelly
AU - Alonso, Alvaro
AU - Tang, Weihong
AU - Lutsey, Pamela L.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Background: Recent evidence suggests that parathyroid hormone (PTH) has effects on vascular smooth muscle cells, the rennin-angiotensin system and kidney function, but less is known about its role in the development of hypertension. The distribution of serum PTH also varies by race. Methods and results: Therefore, we examined the relation between PTH and incident hypertension and tested for interaction by race among 7504 Atherosclerosis Risk in Communities participants (1264 black, 6240 white, median age 56 years) without initial hypertension in 1990-1992. During a median follow-up of 6 years, 1487 white and 509 black participants developed hypertension. In the overall study population, PTH was not associated with incident hypertension after adjustment for demographics and behavioral risk factors [hazard ratio highest vs. lowest quintiles, 95% confidence interval: 1.11 (0.96-1.28); P for linear trend 0.02]. Although the interaction was not statistically significant (P = 0.60), there was some evidence that the PTH-hypertension association differed by race. Among blacks, PTH was positively associated with incident hypertension, independent of demographics, and behavioral risk factors (P for linear trend 0.003). Among whites, PTH was not associated with hypertension risk. Results were similar when comparing participants with elevated versus nonelevated PTH (≥65 vs.
AB - Background: Recent evidence suggests that parathyroid hormone (PTH) has effects on vascular smooth muscle cells, the rennin-angiotensin system and kidney function, but less is known about its role in the development of hypertension. The distribution of serum PTH also varies by race. Methods and results: Therefore, we examined the relation between PTH and incident hypertension and tested for interaction by race among 7504 Atherosclerosis Risk in Communities participants (1264 black, 6240 white, median age 56 years) without initial hypertension in 1990-1992. During a median follow-up of 6 years, 1487 white and 509 black participants developed hypertension. In the overall study population, PTH was not associated with incident hypertension after adjustment for demographics and behavioral risk factors [hazard ratio highest vs. lowest quintiles, 95% confidence interval: 1.11 (0.96-1.28); P for linear trend 0.02]. Although the interaction was not statistically significant (P = 0.60), there was some evidence that the PTH-hypertension association differed by race. Among blacks, PTH was positively associated with incident hypertension, independent of demographics, and behavioral risk factors (P for linear trend 0.003). Among whites, PTH was not associated with hypertension risk. Results were similar when comparing participants with elevated versus nonelevated PTH (≥65 vs.
KW - Cohort study
KW - Hypertension
KW - Parathyroid hormone
KW - Race disparity
UR - http://www.scopus.com/inward/record.url?scp=84957556350&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957556350&partnerID=8YFLogxK
U2 - 10.1097/HJH.0000000000000794
DO - 10.1097/HJH.0000000000000794
M3 - Article
C2 - 26867053
AN - SCOPUS:84957556350
VL - 34
SP - 196
EP - 203
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - 2
ER -