Parathyroid hormone and the risk of incident hypertension: The Atherosclerosis Risk in Communities study

Lu Yao, Aaron R. Folsom, James S. Pankow, Elizabeth Selvin, Erin Donnelly Michos, Alvaro Alonso, Weihong Tang, Pamela L. Lutsey

Research output: Contribution to journalArticle

Abstract

Background: Recent evidence suggests that parathyroid hormone (PTH) has effects on vascular smooth muscle cells, the rennin-angiotensin system and kidney function, but less is known about its role in the development of hypertension. The distribution of serum PTH also varies by race. Methods and results: Therefore, we examined the relation between PTH and incident hypertension and tested for interaction by race among 7504 Atherosclerosis Risk in Communities participants (1264 black, 6240 white, median age 56 years) without initial hypertension in 1990-1992. During a median follow-up of 6 years, 1487 white and 509 black participants developed hypertension. In the overall study population, PTH was not associated with incident hypertension after adjustment for demographics and behavioral risk factors [hazard ratio highest vs. lowest quintiles, 95% confidence interval: 1.11 (0.96-1.28); P for linear trend 0.02]. Although the interaction was not statistically significant (P = 0.60), there was some evidence that the PTH-hypertension association differed by race. Among blacks, PTH was positively associated with incident hypertension, independent of demographics, and behavioral risk factors (P for linear trend 0.003). Among whites, PTH was not associated with hypertension risk. Results were similar when comparing participants with elevated versus nonelevated PTH (≥65 vs.

Original languageEnglish (US)
Pages (from-to)196-203
Number of pages8
JournalJournal of Hypertension
Volume34
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Parathyroid Hormone
Atherosclerosis
Hypertension
Demography
Chymosin
Angiotensins
Vascular Smooth Muscle
Smooth Muscle Myocytes
Confidence Intervals
Kidney
Serum
Population

Keywords

  • Cohort study
  • Hypertension
  • Parathyroid hormone
  • Race disparity

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Parathyroid hormone and the risk of incident hypertension : The Atherosclerosis Risk in Communities study. / Yao, Lu; Folsom, Aaron R.; Pankow, James S.; Selvin, Elizabeth; Michos, Erin Donnelly; Alonso, Alvaro; Tang, Weihong; Lutsey, Pamela L.

In: Journal of Hypertension, Vol. 34, No. 2, 01.02.2016, p. 196-203.

Research output: Contribution to journalArticle

Yao, Lu ; Folsom, Aaron R. ; Pankow, James S. ; Selvin, Elizabeth ; Michos, Erin Donnelly ; Alonso, Alvaro ; Tang, Weihong ; Lutsey, Pamela L. / Parathyroid hormone and the risk of incident hypertension : The Atherosclerosis Risk in Communities study. In: Journal of Hypertension. 2016 ; Vol. 34, No. 2. pp. 196-203.
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