Parathyroid hormone and calcium entry blockade in a vascular tissue

Peter K.T. Pang; May C.M. Yang; James S.K. Sham

doi:10.1016/0024-3205(88)90169-5

Parathyroid hormone and calcium entry blockade in a vascular tissue

Peter K.T. Pang, May C.M. Yang, James S.K. Sham

School of Medicine

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The mechanism of the vasorelaxing action of a synthetic parathyroid hormone fragment, bPTH-(1-34), was studied. Rat tail artery helical strips were constricted in vitro with potassium chloride (6×10^-2 M), arginine vasopressin (2 mU/ml) or BAY-K-8644 (3×10^-7 M in the presence of 1.5×10^-2 M KCl). bPTH-(1-34) was able to relax the constricted tissue or to inhibit the constriction. All three constricting agents increased calcium uptake by the vascular tissue as determined by the measurement of the low-affinity lanthanum-resistant pool of calcium. Such increases in calcium uptake were significantly reduced by bPTH-(1-34). These data suggest that PTH may be a natural circulating hormone or chemical capable of inhibiting calcium entry in a vascular tissue.

Original language	English (US)
Pages (from-to)	1395-1400
Number of pages	6
Journal	Life Sciences
Volume	42
Issue number	14
DOIs	https://doi.org/10.1016/0024-3205(88)90169-5
State	Published - 1988

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(88)90169-5

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title = "Parathyroid hormone and calcium entry blockade in a vascular tissue",

abstract = "The mechanism of the vasorelaxing action of a synthetic parathyroid hormone fragment, bPTH-(1-34), was studied. Rat tail artery helical strips were constricted in vitro with potassium chloride (6×10-2 M), arginine vasopressin (2 mU/ml) or BAY-K-8644 (3×10-7 M in the presence of 1.5×10-2 M KCl). bPTH-(1-34) was able to relax the constricted tissue or to inhibit the constriction. All three constricting agents increased calcium uptake by the vascular tissue as determined by the measurement of the low-affinity lanthanum-resistant pool of calcium. Such increases in calcium uptake were significantly reduced by bPTH-(1-34). These data suggest that PTH may be a natural circulating hormone or chemical capable of inhibiting calcium entry in a vascular tissue.",

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T1 - Parathyroid hormone and calcium entry blockade in a vascular tissue

AU - Pang, Peter K.T.

AU - Yang, May C.M.

AU - Sham, James S.K.

PY - 1988

Y1 - 1988

N2 - The mechanism of the vasorelaxing action of a synthetic parathyroid hormone fragment, bPTH-(1-34), was studied. Rat tail artery helical strips were constricted in vitro with potassium chloride (6×10-2 M), arginine vasopressin (2 mU/ml) or BAY-K-8644 (3×10-7 M in the presence of 1.5×10-2 M KCl). bPTH-(1-34) was able to relax the constricted tissue or to inhibit the constriction. All three constricting agents increased calcium uptake by the vascular tissue as determined by the measurement of the low-affinity lanthanum-resistant pool of calcium. Such increases in calcium uptake were significantly reduced by bPTH-(1-34). These data suggest that PTH may be a natural circulating hormone or chemical capable of inhibiting calcium entry in a vascular tissue.

AB - The mechanism of the vasorelaxing action of a synthetic parathyroid hormone fragment, bPTH-(1-34), was studied. Rat tail artery helical strips were constricted in vitro with potassium chloride (6×10-2 M), arginine vasopressin (2 mU/ml) or BAY-K-8644 (3×10-7 M in the presence of 1.5×10-2 M KCl). bPTH-(1-34) was able to relax the constricted tissue or to inhibit the constriction. All three constricting agents increased calcium uptake by the vascular tissue as determined by the measurement of the low-affinity lanthanum-resistant pool of calcium. Such increases in calcium uptake were significantly reduced by bPTH-(1-34). These data suggest that PTH may be a natural circulating hormone or chemical capable of inhibiting calcium entry in a vascular tissue.

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Parathyroid hormone and calcium entry blockade in a vascular tissue

Abstract

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