Paraquat and maneb induced neurotoxicity

Bessy Thrash, Subramaniam Uthayathas, Senthilkumar Karuppagounder, Vishnu Suppiramaniam, Muralikrishnan Dhanasekaran

Research output: Contribution to journalArticle

Abstract

Parkinson's disease is a progressive neurological disorder associated with selective degeneration of nigrostriatal dopaminergic neurons. It is the most common of the neurodegenerative movement disorders, affecting approximately 1% of the population over age 65. Though the exact cause of the neurodegeneration is unknown, it has been shown that environmental factors can contribute to the onset of Parkinson's disease. Parkinsonian symptoms are seen following exposure to the herbicide paraquat, and the fungicide maneb. Furthermore, evidence clearly shows that neurodegeneration develops in environments where workers are co-exposed to paraquat and maneb. These neurotoxins cause a pesticide-induced loss of dopaminergic neurons, inducing a Parkinsonian phenotype. The specific mechanisms by which these environmental neurotoxins affect the nigral dopaminergic neurons are unknown. This gap in mechanistic understanding raises a need for further examination of their cytotoxic effects. Despite advances in pharmacotherapy that have improved quality of life, the mortality rate among Parkinson's disease sufferers remains largely unchanged. There is need for a proactive treatment strategy that could provide neuroprotection or neurorestoration. Since evidence has shown that environmental neurotoxins play an important role in nigral degeneration, there is obviously a need to take a closer look at such toxins since a greater understanding could aid in development of novel pharmacological agents with anti-parkinson and neuroprotective effects. In this review, we intend to examine the role of environmental toxins, namely paraquat and maneb, in the neurotoxicity that leads to dopamine depletion.

Original languageEnglish (US)
Pages (from-to)31-42
Number of pages12
JournalProceedings of the Western Pharmacology Society
Volume50
StatePublished - 2007
Externally publishedYes

Fingerprint

Maneb
Paraquat
Dopaminergic Neurons
Neurotoxins
Parkinson Disease
Substantia Nigra
Movement Disorders
Herbicides
Neuroprotective Agents
Nervous System Diseases
Pesticides
Neurodegenerative Diseases
Dopamine
Quality of Life
Pharmacology
Phenotype
Drug Therapy
Mortality
Population
Therapeutics

ASJC Scopus subject areas

  • Pharmacology

Cite this

Thrash, B., Uthayathas, S., Karuppagounder, S., Suppiramaniam, V., & Dhanasekaran, M. (2007). Paraquat and maneb induced neurotoxicity. Proceedings of the Western Pharmacology Society, 50, 31-42.

Paraquat and maneb induced neurotoxicity. / Thrash, Bessy; Uthayathas, Subramaniam; Karuppagounder, Senthilkumar; Suppiramaniam, Vishnu; Dhanasekaran, Muralikrishnan.

In: Proceedings of the Western Pharmacology Society, Vol. 50, 2007, p. 31-42.

Research output: Contribution to journalArticle

Thrash, B, Uthayathas, S, Karuppagounder, S, Suppiramaniam, V & Dhanasekaran, M 2007, 'Paraquat and maneb induced neurotoxicity', Proceedings of the Western Pharmacology Society, vol. 50, pp. 31-42.
Thrash B, Uthayathas S, Karuppagounder S, Suppiramaniam V, Dhanasekaran M. Paraquat and maneb induced neurotoxicity. Proceedings of the Western Pharmacology Society. 2007;50:31-42.
Thrash, Bessy ; Uthayathas, Subramaniam ; Karuppagounder, Senthilkumar ; Suppiramaniam, Vishnu ; Dhanasekaran, Muralikrishnan. / Paraquat and maneb induced neurotoxicity. In: Proceedings of the Western Pharmacology Society. 2007 ; Vol. 50. pp. 31-42.
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