TY - JOUR
T1 - Paraneoplastic syndromes in patients with laryngeal neuroendocrine carcinomas
T2 - clinical manifestations and prognostic significance
AU - Ferlito, Alfio
AU - Rinaldo, Alessandra
AU - Bishop, Justin A.
AU - Hunt, Jennifer L.
AU - Vander Poorten, Vincent
AU - Williams, Michelle D.
AU - Triantafyllou, Asterios
AU - Devaney, Kenneth O.
AU - Gnepp, Douglas R.
AU - Kusafuka, Kimihide
AU - Halmos, Gyorgy B.
AU - Westra, William H.
AU - Takes, Robert P.
AU - Thompson, Lester D.R.
N1 - Publisher Copyright:
© 2014, Springer-Verlag Berlin Heidelberg.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Paraneoplastic syndromes are associated with a variety of malignant neoplasms and are systemic and non-metastatic manifestations that develop in a minority of cancer patients. This review examines all published cases of paraneoplastic syndromes associated with neuroendocrine carcinomas of the larynx. There are a total of ten patients reported with paraneoplastic syndromes associated with laryngeal neuroendocrine carcinomas in the literature. Of these, nine died and the tenth is alive with liver metastases. There were five cases of small-cell neuroendocrine carcinoma, four cases of moderately differentiated neuroendocrine carcinoma, and one case of well-differentiated neuroendocrine carcinoma associated with paraneoplastic syndromes. As these syndromes have significant clinical relevance, physicians should be aware of the possible presence of paraneoplastic syndromes in the diagnostic process of patients with neuroendocrine carcinoma of the larynx.
AB - Paraneoplastic syndromes are associated with a variety of malignant neoplasms and are systemic and non-metastatic manifestations that develop in a minority of cancer patients. This review examines all published cases of paraneoplastic syndromes associated with neuroendocrine carcinomas of the larynx. There are a total of ten patients reported with paraneoplastic syndromes associated with laryngeal neuroendocrine carcinomas in the literature. Of these, nine died and the tenth is alive with liver metastases. There were five cases of small-cell neuroendocrine carcinoma, four cases of moderately differentiated neuroendocrine carcinoma, and one case of well-differentiated neuroendocrine carcinoma associated with paraneoplastic syndromes. As these syndromes have significant clinical relevance, physicians should be aware of the possible presence of paraneoplastic syndromes in the diagnostic process of patients with neuroendocrine carcinoma of the larynx.
KW - Diagnosis
KW - Larynx
KW - Neuroendocrine carcinomas
KW - Paraneoplastic syndromes
KW - Prognosis
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U2 - 10.1007/s00405-014-3351-5
DO - 10.1007/s00405-014-3351-5
M3 - Review article
C2 - 25351497
AN - SCOPUS:84959111645
VL - 273
SP - 533
EP - 536
JO - European Archives of Oto-Rhino-Laryngology
JF - European Archives of Oto-Rhino-Laryngology
SN - 0937-4477
IS - 3
ER -