Paraneoplastic syndromes in patients with laryngeal neuroendocrine carcinomas: clinical manifestations and prognostic significance

Alfio Ferlito; Alessandra Rinaldo; Justin A. Bishop; Jennifer L. Hunt; Vincent Vander Poorten; Michelle D. Williams; Asterios Triantafyllou; Kenneth O. Devaney; Douglas R. Gnepp; Kimihide Kusafuka; Gyorgy B. Halmos; William H. Westra; Robert P. Takes; Lester D.R. Thompson

doi:10.1007/s00405-014-3351-5

Paraneoplastic syndromes in patients with laryngeal neuroendocrine carcinomas: clinical manifestations and prognostic significance

Alfio Ferlito, Alessandra Rinaldo, Justin A. Bishop, Jennifer L. Hunt, Vincent Vander Poorten, Michelle D. Williams, Asterios Triantafyllou, Kenneth O. Devaney, Douglas R. Gnepp, Kimihide Kusafuka, Gyorgy B. Halmos, William H. Westra, Robert P. Takes, Lester D.R. Thompson

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Paraneoplastic syndromes are associated with a variety of malignant neoplasms and are systemic and non-metastatic manifestations that develop in a minority of cancer patients. This review examines all published cases of paraneoplastic syndromes associated with neuroendocrine carcinomas of the larynx. There are a total of ten patients reported with paraneoplastic syndromes associated with laryngeal neuroendocrine carcinomas in the literature. Of these, nine died and the tenth is alive with liver metastases. There were five cases of small-cell neuroendocrine carcinoma, four cases of moderately differentiated neuroendocrine carcinoma, and one case of well-differentiated neuroendocrine carcinoma associated with paraneoplastic syndromes. As these syndromes have significant clinical relevance, physicians should be aware of the possible presence of paraneoplastic syndromes in the diagnostic process of patients with neuroendocrine carcinoma of the larynx.

Original language	English (US)
Pages (from-to)	533-536
Number of pages	4
Journal	European Archives of Oto-rhino-laryngology
Volume	273
Issue number	3
DOIs	https://doi.org/10.1007/s00405-014-3351-5
State	Published - Mar 1 2016

Keywords

Diagnosis
Larynx
Neuroendocrine carcinomas
Paraneoplastic syndromes
Prognosis

ASJC Scopus subject areas

Otorhinolaryngology

Access to Document

10.1007/s00405-014-3351-5

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Ferlito, A., Rinaldo, A., Bishop, J. A., Hunt, J. L., Vander Poorten, V., Williams, M. D., Triantafyllou, A., Devaney, K. O., Gnepp, D. R., Kusafuka, K., Halmos, G. B., Westra, W. H., Takes, R. P., & Thompson, L. D. R. (2016). Paraneoplastic syndromes in patients with laryngeal neuroendocrine carcinomas: clinical manifestations and prognostic significance. European Archives of Oto-rhino-laryngology, 273(3), 533-536. https://doi.org/10.1007/s00405-014-3351-5

Paraneoplastic syndromes in patients with laryngeal neuroendocrine carcinomas : clinical manifestations and prognostic significance. / Ferlito, Alfio; Rinaldo, Alessandra; Bishop, Justin A.; Hunt, Jennifer L.; Vander Poorten, Vincent; Williams, Michelle D.; Triantafyllou, Asterios; Devaney, Kenneth O.; Gnepp, Douglas R.; Kusafuka, Kimihide; Halmos, Gyorgy B.; Westra, William H.; Takes, Robert P.; Thompson, Lester D.R.

In: European Archives of Oto-rhino-laryngology, Vol. 273, No. 3, 01.03.2016, p. 533-536.

Research output: Contribution to journal › Review article › peer-review

Ferlito, A, Rinaldo, A, Bishop, JA, Hunt, JL, Vander Poorten, V, Williams, MD, Triantafyllou, A, Devaney, KO, Gnepp, DR, Kusafuka, K, Halmos, GB, Westra, WH, Takes, RP & Thompson, LDR 2016, 'Paraneoplastic syndromes in patients with laryngeal neuroendocrine carcinomas: clinical manifestations and prognostic significance', European Archives of Oto-rhino-laryngology, vol. 273, no. 3, pp. 533-536. https://doi.org/10.1007/s00405-014-3351-5

Ferlito, Alfio ; Rinaldo, Alessandra ; Bishop, Justin A. ; Hunt, Jennifer L. ; Vander Poorten, Vincent ; Williams, Michelle D. ; Triantafyllou, Asterios ; Devaney, Kenneth O. ; Gnepp, Douglas R. ; Kusafuka, Kimihide ; Halmos, Gyorgy B. ; Westra, William H. ; Takes, Robert P. ; Thompson, Lester D.R. / Paraneoplastic syndromes in patients with laryngeal neuroendocrine carcinomas : clinical manifestations and prognostic significance. In: European Archives of Oto-rhino-laryngology. 2016 ; Vol. 273, No. 3. pp. 533-536.

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abstract = "Paraneoplastic syndromes are associated with a variety of malignant neoplasms and are systemic and non-metastatic manifestations that develop in a minority of cancer patients. This review examines all published cases of paraneoplastic syndromes associated with neuroendocrine carcinomas of the larynx. There are a total of ten patients reported with paraneoplastic syndromes associated with laryngeal neuroendocrine carcinomas in the literature. Of these, nine died and the tenth is alive with liver metastases. There were five cases of small-cell neuroendocrine carcinoma, four cases of moderately differentiated neuroendocrine carcinoma, and one case of well-differentiated neuroendocrine carcinoma associated with paraneoplastic syndromes. As these syndromes have significant clinical relevance, physicians should be aware of the possible presence of paraneoplastic syndromes in the diagnostic process of patients with neuroendocrine carcinoma of the larynx.",

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AU - Triantafyllou, Asterios

AU - Devaney, Kenneth O.

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AB - Paraneoplastic syndromes are associated with a variety of malignant neoplasms and are systemic and non-metastatic manifestations that develop in a minority of cancer patients. This review examines all published cases of paraneoplastic syndromes associated with neuroendocrine carcinomas of the larynx. There are a total of ten patients reported with paraneoplastic syndromes associated with laryngeal neuroendocrine carcinomas in the literature. Of these, nine died and the tenth is alive with liver metastases. There were five cases of small-cell neuroendocrine carcinoma, four cases of moderately differentiated neuroendocrine carcinoma, and one case of well-differentiated neuroendocrine carcinoma associated with paraneoplastic syndromes. As these syndromes have significant clinical relevance, physicians should be aware of the possible presence of paraneoplastic syndromes in the diagnostic process of patients with neuroendocrine carcinoma of the larynx.

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