Paraneoplastic pemphigus in a dog with splenic sarcoma

S. A. Elmore, J. Basseches, G. J. Anhalt, J. M. Cullen, T. Olivry

Research output: Contribution to journalArticle

Abstract

Paraneoplastic pemphigus (PNP) is an autoimmune blistering skin disease of humans that consists of characteristic skin lesions associated with concurrent neoplasia. In this study we provide histologic and serologic evidence to support a diagnosis of PNP in a dog with splenic sarcoma. Skin lesions consisted of widespread erosions involving haired skin, mucocutaneous junctions, and oral mucosa. Microscopic examination of skin and mucosae revealed lesions consistent with both pemphigus vulgaris and erythema multiforme. Immunoprecipitation confirmed that circulating IgG autoantibodies from this patient recognized five distinct antigens, presumed to represent epidermal plakins. Clinical, histopathologic, and immunologic findings in this patient were similar to those observed in human patients with PNP. The splenic neoplasia in this dog was diagnosed as a phenotypically variable spindle cell sarcoma. To date, only one other dog has been reported with PNP. This is the second reported case of canine PNP and the first patient in whom skin lesions were identified in association with splenic neoplasia.

Original languageEnglish (US)
Pages (from-to)88-91
Number of pages4
JournalVeterinary pathology
Volume42
Issue number1
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

Keywords

  • Autoantibodies
  • Autoimmunity
  • Blistering skin disease
  • Canine
  • Erythema multiforme
  • Immunoblotting
  • Immunofluorescence
  • Immunoprecipitation
  • Neoplasia
  • Pemphigus
  • Skin
  • Spleen

ASJC Scopus subject areas

  • veterinary(all)

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  • Cite this

    Elmore, S. A., Basseches, J., Anhalt, G. J., Cullen, J. M., & Olivry, T. (2005). Paraneoplastic pemphigus in a dog with splenic sarcoma. Veterinary pathology, 42(1), 88-91. https://doi.org/10.1354/vp.42-1-88