Paraneoplastic pemphigus appearing as bullous pemphigoid-like eruption after palliative radiation therapy

Richard Fried, Yelva Lynfield, Patricia Vitale, Grant Anhalt

Research output: Contribution to journalArticle

Abstract

Paraneoplastic pemphigus is a recently described disease in which patients have polymorphous skin lesions suggestive of both erythema multiforme major and pemphigus vulgaris in association with internal neoplasms, especially non-Hodgkin's lymphoma. These patients have characteristic autoantibodies that bind specific epidermal proteins. A Nikolsky-negative bullous pemphigoid-like eruption developed within the radiation therapy field in a 72-year-old man receiving palliative treatment for recurrent large cell lymphoma. The eruption rapidly progressed to a Nikolsky-positive bullous process more typical of pemphigus vulgaris with extensive involvement of respiratory epithelia. Despite aggressive treatment with high-dose corticosteroids and antibiotics, the patient rapidly succumbed. Results of immunofluorescence studies and autopsy findings confirmed the diagnosis of paraneoplastic pemphigus.

Original languageEnglish (US)
Pages (from-to)815-817
Number of pages3
JournalJournal of the American Academy of Dermatology
Volume29
Issue number5
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Dermatology

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