Paraneoplastic Muscle Disease

Research output: Contribution to journalReview articlepeer-review

Abstract

In paraneoplastic muscle disease, the malignancy may remotely affect neuromuscular transmission or incite muscle inflammation or necrosis. In several of these diseases, an autoimmune basis for the muscle disease has been established and has become a defining feature. These paraneoplastic muscle diseases may be the first manifestation of a malignancy, and their diagnosis thus demands a vigilant search for an underlying tumor. This article is focused on inflammatory and necrotizing myopathies and disorders of neuromuscular transmission that may arise in the setting of malignancy and are considered paraneoplastic phenomena.

Original languageEnglish (US)
Pages (from-to)185-200
Number of pages16
JournalRheumatic Disease Clinics of North America
Volume37
Issue number2
DOIs
StatePublished - May 2011

Keywords

  • Dermatomyositis
  • Eaton-Lambert syndrome
  • Malignancy
  • Myasthenia gravis
  • Myopathy
  • Paraneoplastic
  • Polymyositis
  • Stiff person syndrome

ASJC Scopus subject areas

  • Rheumatology

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