Abstract
In paraneoplastic muscle disease, the malignancy may remotely affect neuromuscular transmission or incite muscle inflammation or necrosis. In several of these diseases, an autoimmune basis for the muscle disease has been established and has become a defining feature. These paraneoplastic muscle diseases may be the first manifestation of a malignancy, and their diagnosis thus demands a vigilant search for an underlying tumor. This article is focused on inflammatory and necrotizing myopathies and disorders of neuromuscular transmission that may arise in the setting of malignancy and are considered paraneoplastic phenomena.
Original language | English (US) |
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Pages (from-to) | 185-200 |
Number of pages | 16 |
Journal | Rheumatic Disease Clinics of North America |
Volume | 37 |
Issue number | 2 |
DOIs | |
State | Published - May 2011 |
Keywords
- Dermatomyositis
- Eaton-Lambert syndrome
- Malignancy
- Myasthenia gravis
- Myopathy
- Paraneoplastic
- Polymyositis
- Stiff person syndrome
ASJC Scopus subject areas
- Rheumatology