Paraneoplastic fasciitis - Panniculitis syndrome: A neurological point of view

Pradeep Dinakar, Ahmet Hoke

Research output: Contribution to journalArticle

Abstract

Background: A 54-year-old woman who had undergone gastrectomy to treat gastric adenocarcinoma 5 years previously and had since been in remission presented to a neuromuscular clinic complaining of stiffening and painful spasms of the legs and abdomen. Repeat pan-CT scans and gastric biopsy confirmed the recurrence of poorly differentiated signet ring gastric adenocarcinoma. Her symptoms improved remarkably on initiation of chemotherapy and worsened on discontinuation of chemotherapy. Investigations: Neurological examination, MRI of the abdomen and lower extremities, whole-body fluorodeoxyglucose PET, pan-CT scan, electromyography, muscle biopsy, upper gastrointestinal tract radiography, esophagogastroduodenoscopy, and immunophenotyping (paraneoplastic, rheumatological and autoimmune diseases panels). Diagnosis: Paraneoplastic fasciitis-panniculitis syndrome associated with the recurrence of poorly differentiated signet ring gastric adenocarcinoma. Management: Chemotherapy of recurrent gastric adenocarcinoma and symptomatic management of painful spasms.

Original languageEnglish (US)
Pages (from-to)113-117
Number of pages5
JournalNature Clinical Practice Neurology
Volume5
Issue number2
DOIs
StatePublished - 2009

Fingerprint

Fasciitis
Panniculitis
Stomach
Adenocarcinoma
Spasm
Drug Therapy
Abdomen
Digestive System Endoscopy
Biopsy
Recurrence
Immunophenotyping
Upper Gastrointestinal Tract
Neurologic Examination
Electromyography
Gastrectomy
Radiography
Autoimmune Diseases
Lower Extremity
Leg
Muscles

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Paraneoplastic fasciitis - Panniculitis syndrome : A neurological point of view. / Dinakar, Pradeep; Hoke, Ahmet.

In: Nature Clinical Practice Neurology, Vol. 5, No. 2, 2009, p. 113-117.

Research output: Contribution to journalArticle

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