Paraneoplastic Autonomic Dysfunction

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Paraneoplastic autonomic dysfunction (PAD) may be immune-mediated or nonimmune-mediated. Paraneoplastic disorder should be suspected in patients with progressive autonomic symptoms, such as orthostatic hypotension, dry mouth, urinary retention, and constipation. Occurrence of sleep apnea, pseudomyotonia, myokymia, pseudoobstruction of bowels, or progressive proprioceptive deficit should strengthen this suspicion. The diagnosis is made by the exclusion of other causes of autonomic dysfunction; electrophysiologic studies in patients with neuromyotonia or suspected Lambert-Eaton myasthenic syndrome; and serologic studies indicating the presence of Anti-Hu/antineuronal nuclear antibody-1, enteric neuronal antibodies, and/or ganglionic acetylcholine receptor (AChR) autoantibodies. A proper diagnosis can spare the patients of unnecessary surgeries in cases of pseudoobstruction of the bowels. Treatment may be directed at the tumor, the antibodies, and the symptoms. An early surgical and cytotoxic reduction of the tumor may diminish autonomic dysfunction in some patients. Use of steroids, plasmapheresis, intravenous (IV) immunoglobulin, or immunosuppression with cyclophosphamide to reduce the antibody may provide benefit.

Original languageEnglish (US)
Title of host publicationPrimer on the Autonomic Nervous System
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages388-390
Number of pages3
ISBN (Electronic)9780080473963
ISBN (Print)9780125897624
DOIs
StatePublished - May 5 2004
Externally publishedYes

Fingerprint

Nervous System Paraneoplastic Syndromes
Isaacs Syndrome
Antibodies
Myokymia
Lambert-Eaton Myasthenic Syndrome
Neoplasm Antibodies
Unnecessary Procedures
Orthostatic Hypotension
Urinary Retention
Plasmapheresis
Intravenous Immunoglobulins
Sleep Apnea Syndromes
Cholinergic Receptors
Constipation
Autoantibodies
Cyclophosphamide
Immunosuppression
Mouth
Steroids
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Khurana, R. (2004). Paraneoplastic Autonomic Dysfunction. In Primer on the Autonomic Nervous System: Second Edition (pp. 388-390). Elsevier Inc.. https://doi.org/10.1016/B978-012589762-4/50106-7

Paraneoplastic Autonomic Dysfunction. / Khurana, Ramesh.

Primer on the Autonomic Nervous System: Second Edition. Elsevier Inc., 2004. p. 388-390.

Research output: Chapter in Book/Report/Conference proceedingChapter

Khurana, R 2004, Paraneoplastic Autonomic Dysfunction. in Primer on the Autonomic Nervous System: Second Edition. Elsevier Inc., pp. 388-390. https://doi.org/10.1016/B978-012589762-4/50106-7
Khurana R. Paraneoplastic Autonomic Dysfunction. In Primer on the Autonomic Nervous System: Second Edition. Elsevier Inc. 2004. p. 388-390 https://doi.org/10.1016/B978-012589762-4/50106-7
Khurana, Ramesh. / Paraneoplastic Autonomic Dysfunction. Primer on the Autonomic Nervous System: Second Edition. Elsevier Inc., 2004. pp. 388-390
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