Parametric study of different contributors to tumor thermal profile

Michal Tepper, Israel Gannot

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Treating cancer is one of the major challenges of modern medicine. There is great interest in assessing tumor development in in vivo animal and human models, as well as in in vitro experiments. Existing methods are either limited by cost and availability or by their low accuracy and reproducibility. Thermography holds the potential of being a noninvasive, low-cost, irradiative and easy-to-use method for tumor monitoring. Tumors can be detected in thermal images due to their relatively higher or lower temperature compared to the temperature of the healthy skin surrounding them. Extensive research is performed to show the validity of thermography as an efficient method for tumor detection and the possibility of extracting tumor properties from thermal images, showing promising results. However, deducing from one type of experiment to others is difficult due to the differences in tumor properties, especially between different types of tumors or different species. There is a need in a research linking different types of tumor experiments. In this research, parametric analysis of possible contributors to tumor thermal profiles was performed. The effect of tumor geometric, physical and thermal properties was studied, both independently and together, in phantom model experiments and computer simulations. Theoretical and experimental results were cross-correlated to validate the models used and increase the accuracy of simulated complex tumor models. The contribution of different parameters in various tumor scenarios was estimated and the implication of these differences on the observed thermal profiles was studied. The correlation between animal and human models is discussed.

Original languageEnglish (US)
Title of host publicationOptical Biopsy XII
PublisherSPIE
ISBN (Print)9780819498533
DOIs
StatePublished - Jan 1 2014
Externally publishedYes
EventOptical Biopsy XII - San Francisco, CA, United States
Duration: Feb 4 2014Feb 5 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8940
ISSN (Print)1605-7422

Conference

ConferenceOptical Biopsy XII
CountryUnited States
CitySan Francisco, CA
Period2/4/142/5/14

Keywords

  • Cancer
  • In vivo imaging
  • Parametric study
  • Phantom experiments
  • Simulation
  • Thermal imaging
  • Thermography
  • Tumor monitoring

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Tepper, M., & Gannot, I. (2014). Parametric study of different contributors to tumor thermal profile. In Optical Biopsy XII [89400P] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8940). SPIE. https://doi.org/10.1117/12.2040745