Parametric and regional maps of free serotonin 5HT1A receptor sites in human brain as function of age in healthy humans

Mette Møller, Steen Jakobsen, Albert Gjedde

Research output: Contribution to journalArticle

Abstract

Serotonin 5HT1A-binding sites can be detected in living human brain with the positron-emitting antagonist [11C]WAY-100635. Previous measurements of the availability of [11C]WAY-binding sites in normal aging are equivocal, in part because of the greatly variable binding of this ligand. To test the null hypothesis that the binding potential (pB) of 5HT 1A sites remains constant with age; 19 healthy volunteers aged 23-73 years (8 women, 11 men) underwent positron emission tomography. To determine pBs, we applied a novel tissue reference method of analysis, Estimation of Reversible Ligand Binding and Receptor Density (ERLiBIiRD) (Gjedde, 2003; Rosa-Neto et al, 2004), which extrapolates measures of specific binding to an estimated steady-state. We compared these estimates in the two age groups with results obtained with the conventional Logan Plot and Simplified Reference Tissue Method (SRTM) applied to both regions of interest-based as parametric analyses. The regional distribution of specific binding of free sites [ 11C]WAY-100635 was similar to that reported in previous studies, with the highest pBs in limbic structures and the raphé nuclei. Although the results of the three methods differed, pBs in the elderly subjects consistently were lower than those of young subjects. Thus, the correlation between pB and age applied to regions-of-interest revealed significant decline of pB at the rate of 3 or 4% per decade, and a 10% decline of the global mean 5HT 1A receptor-pB in elderly relative to young subjects. The results demonstrate that the number of available 5HT1A-binding sites declines with age.

Original languageEnglish (US)
Pages (from-to)1707-1714
Number of pages8
JournalNeuropsychopharmacology
Volume32
Issue number8
DOIs
StatePublished - Aug 2007
Externally publishedYes

Fingerprint

Serotonin Receptors
Binding Sites
Brain
Ligands
Positron-Emission Tomography
Serotonin
Healthy Volunteers
Age Groups
Electrons
N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide

Keywords

  • [C]WAY-100635
  • Aging
  • Brain
  • PET
  • Serotonin 5HT receptors

ASJC Scopus subject areas

  • Pharmacology

Cite this

Parametric and regional maps of free serotonin 5HT1A receptor sites in human brain as function of age in healthy humans. / Møller, Mette; Jakobsen, Steen; Gjedde, Albert.

In: Neuropsychopharmacology, Vol. 32, No. 8, 08.2007, p. 1707-1714.

Research output: Contribution to journalArticle

Møller, Mette ; Jakobsen, Steen ; Gjedde, Albert. / Parametric and regional maps of free serotonin 5HT1A receptor sites in human brain as function of age in healthy humans. In: Neuropsychopharmacology. 2007 ; Vol. 32, No. 8. pp. 1707-1714.
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