Abstract
Safe parameters for electrical cortical stimulation in humans are difficult to estimate from the animal experimental literature. We therefore examined the light microscopic histology at a total of 11 sites of direct subdural electrical stimulation, taken as part of anterior temporal lobectomies in 3 patients. Stimulations had been done through 3.175 mm diameter electrodes, with 0.3 msec square wave pulses of alternating polarity at 50 pulses/sec. In 2 patients, one site each had been used as a common reference for stimulation, receiving over 251 stimulation trials, most of 2-5 sec duration, at currents of 12.5-15.0 mA, 1 day prior to resection. The maximum charge per phase was 4.0-4.4 μC; the maximum charge density was 52-57 μC per geometric cm2 per pulse at the electrode surfaces. Comparison of hematoxylin and eosin, periodic acid-Schiff, and cresyl violet-stained material from the electrode sites with that from other regions did not show any histologic abnormalities attributable to the electrical stimulation. The relatively brief and intermittent periods utilized for human stimulation testing do not appear to cause strcutural damage at the light microscopic level at charge densities that exceed the threshold for damage established in animal studies with more continuous, chronic stimulation schedules.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 371-377 |
| Number of pages | 7 |
| Journal | Electroencephalography and Clinical Neurophysiology |
| Volume | 75 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1990 |
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Keywords
- (Human)
- Electrical cortical stimulation
- Histopathology
- Safety
- Subdural arrays
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Parameters for direct cortical electrical stimulation in the human : histopathologic confirmation. / Gordon, Barry; Lesser, Ronald P; Rance, Naomi E.; Hart, John; Webber, William; Uematsu, Sumio; Fisher, Robert S.
In: Electroencephalography and Clinical Neurophysiology, Vol. 75, No. 5, 1990, p. 371-377.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Parameters for direct cortical electrical stimulation in the human
T2 - histopathologic confirmation
AU - Gordon, Barry
AU - Lesser, Ronald P
AU - Rance, Naomi E.
AU - Hart, John
AU - Webber, William
AU - Uematsu, Sumio
AU - Fisher, Robert S.
PY - 1990
Y1 - 1990
N2 - Safe parameters for electrical cortical stimulation in humans are difficult to estimate from the animal experimental literature. We therefore examined the light microscopic histology at a total of 11 sites of direct subdural electrical stimulation, taken as part of anterior temporal lobectomies in 3 patients. Stimulations had been done through 3.175 mm diameter electrodes, with 0.3 msec square wave pulses of alternating polarity at 50 pulses/sec. In 2 patients, one site each had been used as a common reference for stimulation, receiving over 251 stimulation trials, most of 2-5 sec duration, at currents of 12.5-15.0 mA, 1 day prior to resection. The maximum charge per phase was 4.0-4.4 μC; the maximum charge density was 52-57 μC per geometric cm2 per pulse at the electrode surfaces. Comparison of hematoxylin and eosin, periodic acid-Schiff, and cresyl violet-stained material from the electrode sites with that from other regions did not show any histologic abnormalities attributable to the electrical stimulation. The relatively brief and intermittent periods utilized for human stimulation testing do not appear to cause strcutural damage at the light microscopic level at charge densities that exceed the threshold for damage established in animal studies with more continuous, chronic stimulation schedules.
AB - Safe parameters for electrical cortical stimulation in humans are difficult to estimate from the animal experimental literature. We therefore examined the light microscopic histology at a total of 11 sites of direct subdural electrical stimulation, taken as part of anterior temporal lobectomies in 3 patients. Stimulations had been done through 3.175 mm diameter electrodes, with 0.3 msec square wave pulses of alternating polarity at 50 pulses/sec. In 2 patients, one site each had been used as a common reference for stimulation, receiving over 251 stimulation trials, most of 2-5 sec duration, at currents of 12.5-15.0 mA, 1 day prior to resection. The maximum charge per phase was 4.0-4.4 μC; the maximum charge density was 52-57 μC per geometric cm2 per pulse at the electrode surfaces. Comparison of hematoxylin and eosin, periodic acid-Schiff, and cresyl violet-stained material from the electrode sites with that from other regions did not show any histologic abnormalities attributable to the electrical stimulation. The relatively brief and intermittent periods utilized for human stimulation testing do not appear to cause strcutural damage at the light microscopic level at charge densities that exceed the threshold for damage established in animal studies with more continuous, chronic stimulation schedules.
KW - (Human)
KW - Electrical cortical stimulation
KW - Histopathology
KW - Safety
KW - Subdural arrays
UR - http://www.scopus.com/inward/record.url?scp=0025254540&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025254540&partnerID=8YFLogxK
U2 - 10.1016/0013-4694(90)90082-U
DO - 10.1016/0013-4694(90)90082-U
M3 - Article
C2 - 1692272
AN - SCOPUS:0025254540
VL - 75
SP - 371
EP - 377
JO - Electroencephalography and Clinical Neurophysiology
JF - Electroencephalography and Clinical Neurophysiology
SN - 0013-4694
IS - 5
ER -