Parameters for carbamate pesticide QSAR and PBPK/PD models for human risk assessment

James B. Knaak, Curt C. Dary, Miles S. Okino, Fred W. Power, Xiaofei Zhang, Carol B. Thompson, R. Tornero-Velez, Jerry N. Blancato

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Our interest in providing parameters for the development of quantitative structure physiologically based pharmacokinetic/pharmacodynamic (QSPBPK/PD) models for assessing health risks to carbamates (USEPA 2005) comes from earlier work with organophosphorus (OP) insecticides (Knaak et al. 2004). Parameters specific to each carbamate are needed in the construction of PBPK/PD models along with their metabolic pathways. Parameters may be obtained by (1) development of QSAR models, (2) collecting pharmacokinetic data, and (3) determining pharmacokinetic parameters by fitting to experimental data. The biological parameters are given in Table 1 (Blancato et al. 2000). Table 1 Biological Parameters Required for Carbamate Pesticide Physiologically Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Models.a

Original languageEnglish (US)
Title of host publicationReviews of Environmental Contamination and Toxicology
EditorsDavid Whitacre
Pages53-210
Number of pages158
DOIs
StatePublished - 2008
Externally publishedYes

Publication series

NameReviews of Environmental Contamination and Toxicology
Volume193
ISSN (Print)0179-5953

ASJC Scopus subject areas

  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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