Parameters for carbamate pesticide QSAR and PBPK/PD models for human risk assessment

James B. Knaak; Curt C. Dary; Miles S. Okino; Fred W. Power; Xiaofei Zhang; Carol B. Thompson; R. Tornero-Velez; Jerry N. Blancato

doi:10.1007/978-0-387-73163-6_3

Parameters for carbamate pesticide QSAR and PBPK/PD models for human risk assessment

James B. Knaak, Curt C. Dary, Miles S. Okino, Fred W. Power, Xiaofei Zhang, Carol B. Thompson, R. Tornero-Velez, Jerry N. Blancato

Research output: Chapter in Book/Report/Conference proceeding › Chapter

22 Scopus citations

Abstract

Our interest in providing parameters for the development of quantitative structure physiologically based pharmacokinetic/pharmacodynamic (QSPBPK/PD) models for assessing health risks to carbamates (USEPA 2005) comes from earlier work with organophosphorus (OP) insecticides (Knaak et al. 2004). Parameters specific to each carbamate are needed in the construction of PBPK/PD models along with their metabolic pathways. Parameters may be obtained by (1) development of QSAR models, (2) collecting pharmacokinetic data, and (3) determining pharmacokinetic parameters by fitting to experimental data. The biological parameters are given in Table 1 (Blancato et al. 2000). Table 1 Biological Parameters Required for Carbamate Pesticide Physiologically Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Models.^a

Original language	English (US)
Title of host publication	Reviews of Environmental Contamination and Toxicology
Editors	David Whitacre
Pages	53-210
Number of pages	158
DOIs	https://doi.org/10.1007/978-0-387-73163-6_3
State	Published - 2008
Externally published	Yes

Publication series

Name	Reviews of Environmental Contamination and Toxicology
Volume	193
ISSN (Print)	0179-5953

ASJC Scopus subject areas

Pollution
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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10.1007/978-0-387-73163-6_3

Cite this

Knaak, J. B., Dary, C. C., Okino, M. S., Power, F. W., Zhang, X., Thompson, C. B., Tornero-Velez, R., & Blancato, J. N. (2008). Parameters for carbamate pesticide QSAR and PBPK/PD models for human risk assessment. In D. Whitacre (Ed.), Reviews of Environmental Contamination and Toxicology (pp. 53-210). (Reviews of Environmental Contamination and Toxicology; Vol. 193). https://doi.org/10.1007/978-0-387-73163-6_3

Parameters for carbamate pesticide QSAR and PBPK/PD models for human risk assessment. / Knaak, James B.; Dary, Curt C.; Okino, Miles S. et al.
Reviews of Environmental Contamination and Toxicology. ed. / David Whitacre. 2008. p. 53-210 (Reviews of Environmental Contamination and Toxicology; Vol. 193).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Knaak, JB, Dary, CC, Okino, MS, Power, FW, Zhang, X, Thompson, CB, Tornero-Velez, R & Blancato, JN 2008, Parameters for carbamate pesticide QSAR and PBPK/PD models for human risk assessment. in D Whitacre (ed.), Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology, vol. 193, pp. 53-210. https://doi.org/10.1007/978-0-387-73163-6_3

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abstract = "Our interest in providing parameters for the development of quantitative structure physiologically based pharmacokinetic/pharmacodynamic (QSPBPK/PD) models for assessing health risks to carbamates (USEPA 2005) comes from earlier work with organophosphorus (OP) insecticides (Knaak et al. 2004). Parameters specific to each carbamate are needed in the construction of PBPK/PD models along with their metabolic pathways. Parameters may be obtained by (1) development of QSAR models, (2) collecting pharmacokinetic data, and (3) determining pharmacokinetic parameters by fitting to experimental data. The biological parameters are given in Table 1 (Blancato et al. 2000). Table 1 Biological Parameters Required for Carbamate Pesticide Physiologically Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Models.a",

author = "Knaak, {James B.} and Dary, {Curt C.} and Okino, {Miles S.} and Power, {Fred W.} and Xiaofei Zhang and Thompson, {Carol B.} and R. Tornero-Velez and Blancato, {Jerry N.}",

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AU - Thompson, Carol B.

AU - Tornero-Velez, R.

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Parameters for carbamate pesticide QSAR and PBPK/PD models for human risk assessment

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