Parameters for carbamate pesticide QSAR and PBPK/PD models for human risk assessment

James B. Knaak, Curt C. Dary, Miles S. Okino, Fred W. Power, Xiaofei Zhang, Carol Thompson, R. Tornero-Velez, Jerry N. Blancato

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Our interest in providing parameters for the development of quantitative structure physiologically based pharmacokinetic/pharmacodynamic (QSPBPK/PD) models for assessing health risks to carbamates (USEPA 2005) comes from earlier work with organophosphorus (OP) insecticides (Knaak et al. 2004). Parameters specific to each carbamate are needed in the construction of PBPK/PD models along with their metabolic pathways. Parameters may be obtained by (1) development of QSAR models, (2) collecting pharmacokinetic data, and (3) determining pharmacokinetic parameters by fitting to experimental data. The biological parameters are given in Table 1 (Blancato et al. 2000). Table 1 Biological Parameters Required for Carbamate Pesticide Physiologically Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Models.a

Original languageEnglish (US)
Title of host publicationReviews of Environmental Contamination and Toxicology
Pages53-210
Number of pages158
Volume193
DOIs
StatePublished - 2008
Externally publishedYes

Publication series

NameReviews of Environmental Contamination and Toxicology
Volume193
ISSN (Print)01795953

Fingerprint

Pharmacodynamics
Pharmacokinetics
Carbamates
Quantitative Structure-Activity Relationship
Pesticides
Risk assessment
United States Environmental Protection Agency
Insecticides
Health risks
Metabolic Networks and Pathways
Health

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Pollution
  • Public Health, Environmental and Occupational Health

Cite this

Knaak, J. B., Dary, C. C., Okino, M. S., Power, F. W., Zhang, X., Thompson, C., ... Blancato, J. N. (2008). Parameters for carbamate pesticide QSAR and PBPK/PD models for human risk assessment. In Reviews of Environmental Contamination and Toxicology (Vol. 193, pp. 53-210). (Reviews of Environmental Contamination and Toxicology; Vol. 193). https://doi.org/10.1007/978-0-387-73163-6_3

Parameters for carbamate pesticide QSAR and PBPK/PD models for human risk assessment. / Knaak, James B.; Dary, Curt C.; Okino, Miles S.; Power, Fred W.; Zhang, Xiaofei; Thompson, Carol; Tornero-Velez, R.; Blancato, Jerry N.

Reviews of Environmental Contamination and Toxicology. Vol. 193 2008. p. 53-210 (Reviews of Environmental Contamination and Toxicology; Vol. 193).

Research output: Chapter in Book/Report/Conference proceedingChapter

Knaak, JB, Dary, CC, Okino, MS, Power, FW, Zhang, X, Thompson, C, Tornero-Velez, R & Blancato, JN 2008, Parameters for carbamate pesticide QSAR and PBPK/PD models for human risk assessment. in Reviews of Environmental Contamination and Toxicology. vol. 193, Reviews of Environmental Contamination and Toxicology, vol. 193, pp. 53-210. https://doi.org/10.1007/978-0-387-73163-6_3
Knaak JB, Dary CC, Okino MS, Power FW, Zhang X, Thompson C et al. Parameters for carbamate pesticide QSAR and PBPK/PD models for human risk assessment. In Reviews of Environmental Contamination and Toxicology. Vol. 193. 2008. p. 53-210. (Reviews of Environmental Contamination and Toxicology). https://doi.org/10.1007/978-0-387-73163-6_3
Knaak, James B. ; Dary, Curt C. ; Okino, Miles S. ; Power, Fred W. ; Zhang, Xiaofei ; Thompson, Carol ; Tornero-Velez, R. ; Blancato, Jerry N. / Parameters for carbamate pesticide QSAR and PBPK/PD models for human risk assessment. Reviews of Environmental Contamination and Toxicology. Vol. 193 2008. pp. 53-210 (Reviews of Environmental Contamination and Toxicology).
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