Parameterization of White Matter Manifold-Like Structures Using Principal Surfaces

Chen Yue, Vadim Zipunnikov, Pierre Louis Bazin, Dzung Pham, Daniel Reich, Ciprian M Crainiceanu, Brian S Caffo

Research output: Contribution to journalArticle

Abstract

In this article, we are concerned with data generated from a diffusion tensor imaging (DTI) experiment. The goal is to parameterize manifold-like white matter tracts, such as the corpus callosum, using principal surfaces. The problem is approached by finding a geometrically motivated surface-based representation of the corpus callosum and visualized fractional anisotropy (FA) values projected onto the surface. The method also applies to any other diffusion summary. An algorithm is proposed that (a) constructs the principal surface of a corpus callosum; (b) flattens the surface into a parametric two-dimensional (2D) map; and (c) projects associated FA values on the map. The algorithm is applied to a longitudinal study containing 466 diffusion tensor images of 176 multiple sclerosis (MS) patients observed at multiple visits. For each subject and visit, the study contains a registered DTI scan of the corpus callosum at roughly 20,000 voxels. Extensive simulation studies demonstrate fast convergence and robust performance of the algorithm under a variety of challenging scenarios.

Original languageEnglish (US)
Pages (from-to)1050-1060
Number of pages11
JournalJournal of the American Statistical Association
Volume111
Issue number515
DOIs
StatePublished - Jul 2 2016

Fingerprint

Parameterization
Tensor
Anisotropy
Fractional
Imaging
Flatten
Multiple Sclerosis
Parameterise
Robust Performance
Longitudinal Study
Voxel
Simulation Study
Scenarios
Corpus
Demonstrate
Experiment

Keywords

  • Corpus callosum
  • Principal curves and surfaces
  • Thin plate splines

ASJC Scopus subject areas

  • Statistics and Probability
  • Statistics, Probability and Uncertainty

Cite this

Parameterization of White Matter Manifold-Like Structures Using Principal Surfaces. / Yue, Chen; Zipunnikov, Vadim; Bazin, Pierre Louis; Pham, Dzung; Reich, Daniel; Crainiceanu, Ciprian M; Caffo, Brian S.

In: Journal of the American Statistical Association, Vol. 111, No. 515, 02.07.2016, p. 1050-1060.

Research output: Contribution to journalArticle

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