@article{d39df22edc3b45b884a317aee3f86f04,
title = "Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study",
abstract = "In multiple sclerosis (MS), a subset of chronic active white matter lesions are identifiable on magnetic resonance imaging by their paramagnetic rims, and increasing evidence supports their association with severity of clinical disease. We studied their potential role in differential diagnosis, screening an international multicenter clinical research-based sample of 438 individuals affected by different neurological conditions (MS, other inflammatory, infectious, and non-inflammatory conditions). Paramagnetic rim lesions, rare in other neurological conditions (52% of MS vs 7% of non-MS cases), yielded high specificity (93%) in differentiating MS from non-MS. Future prospective multicenter studies should validate their role as a diagnostic biomarker. ANN NEUROL 2020;88:1034–1042.",
author = "Pietro Maggi and Pascal Sati and Govind Nair and Cortese, {Irene C.M.} and Steven Jacobson and Smith, {Bryan R.} and Avindra Nath and Joan Ohayon and {van Pesch}, Vincent and Gaetano Perrotta and Caroline Pot and Marie Th{\'e}audin and Vittorio Martinelli and Roberta Scotti and Tianxia Wu and {Du Pasquier}, Renaud and Calabresi, {Peter A.} and Massimo Filippi and Reich, {Daniel S.} and Martina Absinta",
note = "Funding Information: The study was partially supported by Intramural Research Program of the NIH/NINDS (to D.S.R.), by NIH/NINDS (grant R01NS082347, to P.A.C.), and by the Conrad N. Hilton Foundation (grant 17313, to M.A.). Funding Information: The study was partially supported by Intramural Research Program of the NIH/NINDS (to D.S.R.), by NIH/NINDS (grant R01NS082347, to P.A.C.), and by the Conrad N. Hilton Foundation (grant 17313, to M.A.). We thank the study participants; the neuroimmunology clinics in each center for recruiting and evaluating the patients and for coordinating the scans; and Blake Dewey, Antonella Iadanza, Tobias Kober, Julie Absil, and Jean-Baptiste Ledoux for assistance with 3T MRI scan acquisition. We thank Dragan Maric for helping with the fluorescent multiplex immunostaining of brain MS autopsy tissue (shown in Fig 1). Publisher Copyright: {\textcopyright} 2020 American Neurological Association",
year = "2020",
month = nov,
day = "1",
doi = "10.1002/ana.25877",
language = "English (US)",
volume = "88",
pages = "1034--1042",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "5",
}