Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study

Pietro Maggi; Pascal Sati; Govind Nair; Irene C.M. Cortese; Steven Jacobson; Bryan R. Smith; Avindra Nath; Joan Ohayon; Vincent van Pesch; Gaetano Perrotta; Caroline Pot; Marie Théaudin; Vittorio Martinelli; Roberta Scotti; Tianxia Wu; Renaud Du Pasquier; Peter A. Calabresi; Massimo Filippi; Daniel S. Reich; Martina Absinta

doi:10.1002/ana.25877

Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study

Pietro Maggi, Pascal Sati, Govind Nair, Irene C.M. Cortese, Steven Jacobson, Bryan R. Smith, Avindra Nath, Joan Ohayon, Vincent van Pesch, Gaetano Perrotta, Caroline Pot, Marie Théaudin, Vittorio Martinelli, Roberta Scotti, Tianxia Wu, Renaud Du Pasquier, Peter A. Calabresi, Massimo Filippi, Daniel S. Reich, Martina Absinta

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

In multiple sclerosis (MS), a subset of chronic active white matter lesions are identifiable on magnetic resonance imaging by their paramagnetic rims, and increasing evidence supports their association with severity of clinical disease. We studied their potential role in differential diagnosis, screening an international multicenter clinical research-based sample of 438 individuals affected by different neurological conditions (MS, other inflammatory, infectious, and non-inflammatory conditions). Paramagnetic rim lesions, rare in other neurological conditions (52% of MS vs 7% of non-MS cases), yielded high specificity (93%) in differentiating MS from non-MS. Future prospective multicenter studies should validate their role as a diagnostic biomarker. ANN NEUROL 2020;88:1034–1042.

Original language	English (US)
Pages (from-to)	1034-1042
Number of pages	9
Journal	Annals of neurology
Volume	88
Issue number	5
DOIs	https://doi.org/10.1002/ana.25877
State	Published - Nov 1 2020

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/ana.25877

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Maggi, P., Sati, P., Nair, G., Cortese, I. C. M., Jacobson, S., Smith, B. R., Nath, A., Ohayon, J., van Pesch, V., Perrotta, G., Pot, C., Théaudin, M., Martinelli, V., Scotti, R., Wu, T., Du Pasquier, R., Calabresi, P. A., Filippi, M., Reich, D. S., & Absinta, M. (2020). Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study. Annals of neurology, 88(5), 1034-1042. https://doi.org/10.1002/ana.25877

Paramagnetic Rim Lesions are Specific to Multiple Sclerosis : An International Multicenter 3T MRI Study. / Maggi, Pietro; Sati, Pascal; Nair, Govind; Cortese, Irene C.M.; Jacobson, Steven; Smith, Bryan R.; Nath, Avindra; Ohayon, Joan; van Pesch, Vincent; Perrotta, Gaetano; Pot, Caroline; Théaudin, Marie; Martinelli, Vittorio; Scotti, Roberta; Wu, Tianxia; Du Pasquier, Renaud; Calabresi, Peter A.; Filippi, Massimo; Reich, Daniel S.; Absinta, Martina.

In: Annals of neurology, Vol. 88, No. 5, 01.11.2020, p. 1034-1042.

Research output: Contribution to journal › Article › peer-review

Maggi, P, Sati, P, Nair, G, Cortese, ICM, Jacobson, S, Smith, BR, Nath, A, Ohayon, J, van Pesch, V, Perrotta, G, Pot, C, Théaudin, M, Martinelli, V, Scotti, R, Wu, T, Du Pasquier, R, Calabresi, PA, Filippi, M, Reich, DS & Absinta, M 2020, 'Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study', Annals of neurology, vol. 88, no. 5, pp. 1034-1042. https://doi.org/10.1002/ana.25877

Maggi, Pietro ; Sati, Pascal ; Nair, Govind ; Cortese, Irene C.M. ; Jacobson, Steven ; Smith, Bryan R. ; Nath, Avindra ; Ohayon, Joan ; van Pesch, Vincent ; Perrotta, Gaetano ; Pot, Caroline ; Théaudin, Marie ; Martinelli, Vittorio ; Scotti, Roberta ; Wu, Tianxia ; Du Pasquier, Renaud ; Calabresi, Peter A. ; Filippi, Massimo ; Reich, Daniel S. ; Absinta, Martina. / Paramagnetic Rim Lesions are Specific to Multiple Sclerosis : An International Multicenter 3T MRI Study. In: Annals of neurology. 2020 ; Vol. 88, No. 5. pp. 1034-1042.

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title = "Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study",

abstract = "In multiple sclerosis (MS), a subset of chronic active white matter lesions are identifiable on magnetic resonance imaging by their paramagnetic rims, and increasing evidence supports their association with severity of clinical disease. We studied their potential role in differential diagnosis, screening an international multicenter clinical research-based sample of 438 individuals affected by different neurological conditions (MS, other inflammatory, infectious, and non-inflammatory conditions). Paramagnetic rim lesions, rare in other neurological conditions (52% of MS vs 7% of non-MS cases), yielded high specificity (93%) in differentiating MS from non-MS. Future prospective multicenter studies should validate their role as a diagnostic biomarker. ANN NEUROL 2020;88:1034–1042.",

author = "Pietro Maggi and Pascal Sati and Govind Nair and Cortese, {Irene C.M.} and Steven Jacobson and Smith, {Bryan R.} and Avindra Nath and Joan Ohayon and {van Pesch}, Vincent and Gaetano Perrotta and Caroline Pot and Marie Th{\'e}audin and Vittorio Martinelli and Roberta Scotti and Tianxia Wu and {Du Pasquier}, Renaud and Calabresi, {Peter A.} and Massimo Filippi and Reich, {Daniel S.} and Martina Absinta",

note = "Funding Information: The study was partially supported by Intramural Research Program of the NIH/NINDS (to D.S.R.), by NIH/NINDS (grant R01NS082347, to P.A.C.), and by the Conrad N. Hilton Foundation (grant 17313, to M.A.). We thank the study participants; the neuroimmunology clinics in each center for recruiting and evaluating the patients and for coordinating the scans; and Blake Dewey, Antonella Iadanza, Tobias Kober, Julie Absil, and Jean-Baptiste Ledoux for assistance with 3T MRI scan acquisition. We thank Dragan Maric for helping with the fluorescent multiplex immunostaining of brain MS autopsy tissue (shown in Fig 1).",

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AU - Nath, Avindra

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AU - Martinelli, Vittorio

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AU - Du Pasquier, Renaud

AU - Calabresi, Peter A.

AU - Filippi, Massimo

AU - Reich, Daniel S.

AU - Absinta, Martina

N1 - Funding Information: The study was partially supported by Intramural Research Program of the NIH/NINDS (to D.S.R.), by NIH/NINDS (grant R01NS082347, to P.A.C.), and by the Conrad N. Hilton Foundation (grant 17313, to M.A.). We thank the study participants; the neuroimmunology clinics in each center for recruiting and evaluating the patients and for coordinating the scans; and Blake Dewey, Antonella Iadanza, Tobias Kober, Julie Absil, and Jean-Baptiste Ledoux for assistance with 3T MRI scan acquisition. We thank Dragan Maric for helping with the fluorescent multiplex immunostaining of brain MS autopsy tissue (shown in Fig 1).

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