Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M1 positive allosteric modulators

Feng V. Yang, William D. Shipe, Jaime L. Bunda, M. Brad Nolt, David D. Wisnoski, Zhijian Zhao, James C. Barrow, William J. Ray, Lei Ma, Marion Wittmann, Matthew A. Seager, Kenneth A. Koeplinger, George D. Hartman, Craig W. Lindsley

Research output: Contribution to journalArticle

Abstract

An iterative analog library synthesis approach was employed in the exploration of a quinolone carboxylic acid series of selective M1 positive allosteric modulators, and strategies for improving potency and plasma free fraction were identified.

Original languageEnglish (US)
Pages (from-to)531-536
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number2
DOIs
StatePublished - Jan 15 2010
Externally publishedYes

Keywords

  • M
  • Positive allosteric modulator

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Yang, F. V., Shipe, W. D., Bunda, J. L., Nolt, M. B., Wisnoski, D. D., Zhao, Z., Barrow, J. C., Ray, W. J., Ma, L., Wittmann, M., Seager, M. A., Koeplinger, K. A., Hartman, G. D., & Lindsley, C. W. (2010). Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M1 positive allosteric modulators. Bioorganic and Medicinal Chemistry Letters, 20(2), 531-536. https://doi.org/10.1016/j.bmcl.2009.11.100