TY - JOUR
T1 - Parallel processing streams in the hippocampus
AU - Lee, Heekyung
AU - GoodSmith, Douglas
AU - Knierim, James J.
N1 - Funding Information:
This work was supported by N.I.H. grants PO1 AG009973 and R01 NS039456 .
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/10
Y1 - 2020/10
N2 - The hippocampus performs two complementary processes, pattern separation and pattern completion, to minimize interference and maximize the storage capacity of memories. Classic computational models have suggested that the dentate gyrus (DG) supports pattern separation and the putative attractor circuitry in CA3 supports pattern completion. However, recent evidence of functional heterogeneity along the CA3 transverse axis of the hippocampus suggests that the DG and proximal CA3 work as a functional unit for pattern separation, while distal CA3 forms an autoassociative network for pattern completion. We propose that the outputs of these functional circuits, combined with direct projections from entorhinal cortex to CA1, form interconnected, parallel processing circuits to support accurate memory storage and retrieval.
AB - The hippocampus performs two complementary processes, pattern separation and pattern completion, to minimize interference and maximize the storage capacity of memories. Classic computational models have suggested that the dentate gyrus (DG) supports pattern separation and the putative attractor circuitry in CA3 supports pattern completion. However, recent evidence of functional heterogeneity along the CA3 transverse axis of the hippocampus suggests that the DG and proximal CA3 work as a functional unit for pattern separation, while distal CA3 forms an autoassociative network for pattern completion. We propose that the outputs of these functional circuits, combined with direct projections from entorhinal cortex to CA1, form interconnected, parallel processing circuits to support accurate memory storage and retrieval.
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U2 - 10.1016/j.conb.2020.03.004
DO - 10.1016/j.conb.2020.03.004
M3 - Review article
C2 - 32502734
AN - SCOPUS:85085769001
SN - 0959-4388
VL - 64
SP - 127
EP - 134
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -