Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging

N. D. Volkow; G. J. Wang; J. S. Fowler; Y. S. Ding; R. C. Gur; J. Gatley; J. Logan; P. J. Moberg; R. Hitzemann; G. Smith; N. Pappas

doi:10.1002/ana.410440125

Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging

N. D. Volkow, G. J. Wang, J. S. Fowler, Y. S. Ding, R. C. Gur, J. Gatley, J. Logan, P. J. Moberg, R. Hitzemann, G. Smith, N. Pappas

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143 Scopus citations

Abstract

Aging of the human brain is associated with a decline in dopamine (DA) function, generally interpreted as reflecting DA cell loss. Positron emission tomography studies revealed that in healthy individuals, the age-related losses in DA transporters (presynaptic marker) were associated with losses in D2 receptors (postsynaptic marker) rather than with increases as is known to occur with DA cell loss. This association was specific for DA synaptic markers, because they were not correlated with striatal metabolism. Furthermore, the association was independent of age, suggesting that a common mechanism regulates the expression of receptors and transporters irrespective of age.

Original language	English (US)
Pages (from-to)	143-147
Number of pages	5
Journal	Annals of neurology
Volume	44
Issue number	1
DOIs	https://doi.org/10.1002/ana.410440125
State	Published - Jul 1998
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology

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abstract = "Aging of the human brain is associated with a decline in dopamine (DA) function, generally interpreted as reflecting DA cell loss. Positron emission tomography studies revealed that in healthy individuals, the age-related losses in DA transporters (presynaptic marker) were associated with losses in D2 receptors (postsynaptic marker) rather than with increases as is known to occur with DA cell loss. This association was specific for DA synaptic markers, because they were not correlated with striatal metabolism. Furthermore, the association was independent of age, suggesting that a common mechanism regulates the expression of receptors and transporters irrespective of age.",

author = "Volkow, {N. D.} and Wang, {G. J.} and Fowler, {J. S.} and Ding, {Y. S.} and Gur, {R. C.} and J. Gatley and J. Logan and Moberg, {P. J.} and R. Hitzemann and G. Smith and N. Pappas",

year = "1998",

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AU - Volkow, N. D.

AU - Wang, G. J.

AU - Fowler, J. S.

AU - Ding, Y. S.

AU - Gur, R. C.

AU - Gatley, J.

AU - Logan, J.

AU - Moberg, P. J.

AU - Hitzemann, R.

AU - Smith, G.

AU - Pappas, N.

PY - 1998/7

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AB - Aging of the human brain is associated with a decline in dopamine (DA) function, generally interpreted as reflecting DA cell loss. Positron emission tomography studies revealed that in healthy individuals, the age-related losses in DA transporters (presynaptic marker) were associated with losses in D2 receptors (postsynaptic marker) rather than with increases as is known to occur with DA cell loss. This association was specific for DA synaptic markers, because they were not correlated with striatal metabolism. Furthermore, the association was independent of age, suggesting that a common mechanism regulates the expression of receptors and transporters irrespective of age.

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Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging

Abstract

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