Parallel ICA with multiple references: A semi-blind multivariate approach

Jiayu Chen, Vince D. Calhoun, Alvaro E. Ulloa, Jingyu Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

High data dimensionality poses a major challenge for imaging genomie studies. To address this issue, a semi-blind multivariate approach, parallel independent component analysis with multiple references (pICA-MR), is proposed. pICA-MR extracts imaging and genetic components in parallel and enhances inter-modality correlations. Prior knowledge is incorporated to emphasize genetic factors with specific attributes. Particularly, pICA-MR can investigate multiple genetic references to explore functional interactions among genes. Simulations demonstrate robust performances with Euclidean distance employed as a metric for reference similarity, where components pointed by the same references are reliably identified and the detection power is significantly improved compared to blind methods.

Original languageEnglish (US)
Title of host publication2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages6659-6662
Number of pages4
ISBN (Electronic)9781424479290
DOIs
StatePublished - Nov 2 2014
Event2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, United States
Duration: Aug 26 2014Aug 30 2014

Publication series

Name2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014

Other

Other2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
CountryUnited States
CityChicago
Period8/26/148/30/14

ASJC Scopus subject areas

  • Health Informatics
  • Computer Science Applications
  • Biomedical Engineering
  • Medicine(all)

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  • Cite this

    Chen, J., Calhoun, V. D., Ulloa, A. E., & Liu, J. (2014). Parallel ICA with multiple references: A semi-blind multivariate approach. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 (pp. 6659-6662). [6945155] (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2014.6945155