Parainfluenza virus type 3 Ab in allogeneic hematopoietic cell transplant recipients: factors influencing post-transplant Ab titers and associated outcomes

S. Seo, H. Xie, Ruth A Karron, Bhagvanji Thumar, J. A. Englund, W. M. Leisenring, T. Stevens-Ayers, M. Boeckh, A. P. Campbell

Research output: Contribution to journalArticle

Abstract

Parainfluenza virus type 3 (PIV-3) can cause severe respiratory illness among hematopoietic cell transplantation (HCT) recipients. Factors associated with PIV-3-specific Ab level, and the association between PIV-3 Ab levels and clinical outcomes in HCT recipients who acquire PIV-3 infection, are unknown. We evaluated PIV-3-specific hemagglutination inhibition Ab levels and clinical outcomes among 172 patients with PIV-3 infection following HCT. In a multivariable linear regression model, high post-transplantation Ab levels were independently associated with higher pre-transplantation recipient titer (mean difference 0.38 (95% confidence interval (CI), 0.26, 0.50), P<0.001). Significant associations between pre-HCT Ab titers in both patients and donors and occurrence of lower respiratory tract disease (LRD) after HCT were not observed. In conclusion, low pre-transplantation titers are associated with low Ab levels after HCT. The relationship between PIV-3 Ab levels and outcomes remain uncertain. Further study is needed to prospectively evaluate the dynamics of PIV-3-specific Ab responses and the relative contribution of PIV-3-specific Ab to protection from infection acquisition and progression to LRD.

Original languageEnglish (US)
Pages (from-to)1205-1211
Number of pages7
JournalBone Marrow Transplantation
Volume49
Issue number9
DOIs
StatePublished - Sep 1 2014

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Human parainfluenza virus 3
Cell Transplantation
Transplants
Respiratory Tract Diseases
Paramyxoviridae Infections
Transplantation
Linear Models
Transplant Recipients
Hemagglutination
Tissue Donors
Confidence Intervals

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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Parainfluenza virus type 3 Ab in allogeneic hematopoietic cell transplant recipients : factors influencing post-transplant Ab titers and associated outcomes. / Seo, S.; Xie, H.; Karron, Ruth A; Thumar, Bhagvanji; Englund, J. A.; Leisenring, W. M.; Stevens-Ayers, T.; Boeckh, M.; Campbell, A. P.

In: Bone Marrow Transplantation, Vol. 49, No. 9, 01.09.2014, p. 1205-1211.

Research output: Contribution to journalArticle

Seo, S. ; Xie, H. ; Karron, Ruth A ; Thumar, Bhagvanji ; Englund, J. A. ; Leisenring, W. M. ; Stevens-Ayers, T. ; Boeckh, M. ; Campbell, A. P. / Parainfluenza virus type 3 Ab in allogeneic hematopoietic cell transplant recipients : factors influencing post-transplant Ab titers and associated outcomes. In: Bone Marrow Transplantation. 2014 ; Vol. 49, No. 9. pp. 1205-1211.
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