The BCL2 gene product has been demonstrated to prevent apoptosis and provide a selective growth advantage to many cell types. We report an unexpected effect of bcl2 expression on the in vitro growth of several solid tumor cell lines. Expression of bcl2 in these cell lines resulted in growth inhibition similar to that seen with p53. In contrast, a COOH-terminal deletion mutant of bc12 was unable to suppress growth. Thus, the bcl2 protein may exert distinct biological effects in different cell types.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Jul 1994|
ASJC Scopus subject areas
- Cancer Research