Paradoxical Inhibition of Solid Tumor Cell Growth by bcl2

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Abstract

The BCL2 gene product has been demonstrated to prevent apoptosis and provide a selective growth advantage to many cell types. We report an unexpected effect of bcl2 expression on the in vitro growth of several solid tumor cell lines. Expression of bcl2 in these cell lines resulted in growth inhibition similar to that seen with p53. In contrast, a COOH-terminal deletion mutant of bc12 was unable to suppress growth. Thus, the bcl2 protein may exert distinct biological effects in different cell types.

Original languageEnglish (US)
Pages (from-to)3714-3717
Number of pages4
JournalCancer Research
Volume54
Issue number14
StatePublished - Jul 1994

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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