Paracetamol absorption from a feeding jejunostomy

E. B. Nelson, D. R. Abernethy, D. J. Greenblatt, B. Ameer

Research output: Contribution to journalArticlepeer-review

Abstract

Disposition of paracetamol oral elixir was determined in two male patients after administration via feeding jejunostomy and compared with four male controls who received the same dose by mouth. Area under the plasma concentration-time curve, elimination half-life, and time to maximum concentration were similar in both groups after 650 mg paracetamol elixir. The absolute amounts and ratio of paracetamol glucuronide to sulphate, the major urinary metabolites after therapeutic paracetamol doses, were similar after jejunal administration as compared to oral administration. Paracetamol is absorbed and biotransformed in a similar manner after either jejunal or oral administration. Therefore, it may be administered effectively via jejunostomy tube in patients who require this route of administration.

Original languageEnglish (US)
Pages (from-to)111-113
Number of pages3
JournalBritish Journal of Clinical Pharmacology
Volume22
Issue number1
StatePublished - 1986

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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