Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control

Victoria Aranda, Teresa Haire, Marissa E. Nolan, Joseph P. Calarco, Avi Rosenberg, James P. Fawcett, Tony Pawson, Senthil K. Muthuswamy

Research output: Contribution to journalArticle

Abstract

The polarized glandular organization of epithelial cells is frequently lost during development of carcinoma. However, the specific oncogene targets responsible for polarity disruption have not been identified. Here, we demonstrate that activation of ErbB2 disrupts apical-basal polarity by associating with Par6-aPKC, components of the Par polarity complex. Inhibition of interaction between Par6 and aPKC blocked the ability of ErbB2 to disrupt the acinar organization of breast epithelia and to protect cells from apoptosis but was not required for cell proliferation. Therefore, oncogenes target polarity proteins to disrupt glandular organization and protect cells from apoptotic death during development of carcinoma.

Original languageEnglish (US)
Pages (from-to)1235-1245
Number of pages11
JournalNature Cell Biology
Volume8
Issue number11
DOIs
StatePublished - Nov 2006
Externally publishedYes

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Oncogenes
Carcinoma
Breast
Cell Death
Epithelium
Epithelial Cells
Cell Proliferation
Apoptosis
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

Aranda, V., Haire, T., Nolan, M. E., Calarco, J. P., Rosenberg, A., Fawcett, J. P., ... Muthuswamy, S. K. (2006). Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nature Cell Biology, 8(11), 1235-1245. https://doi.org/10.1038/ncb1485

Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. / Aranda, Victoria; Haire, Teresa; Nolan, Marissa E.; Calarco, Joseph P.; Rosenberg, Avi; Fawcett, James P.; Pawson, Tony; Muthuswamy, Senthil K.

In: Nature Cell Biology, Vol. 8, No. 11, 11.2006, p. 1235-1245.

Research output: Contribution to journalArticle

Aranda, V, Haire, T, Nolan, ME, Calarco, JP, Rosenberg, A, Fawcett, JP, Pawson, T & Muthuswamy, SK 2006, 'Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control', Nature Cell Biology, vol. 8, no. 11, pp. 1235-1245. https://doi.org/10.1038/ncb1485
Aranda, Victoria ; Haire, Teresa ; Nolan, Marissa E. ; Calarco, Joseph P. ; Rosenberg, Avi ; Fawcett, James P. ; Pawson, Tony ; Muthuswamy, Senthil K. / Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. In: Nature Cell Biology. 2006 ; Vol. 8, No. 11. pp. 1235-1245.
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