Papovavirus of JC Type in Progressive Multifocal Leukoencephalopathy: Rapid Identification and Subsequent Isolation

Leslie P. Weiner; Opendra Narayan; John B. Penney; Robert M. Herndon; Earl R. Feringa; Richard T. Johnson; Wallace W. Tourtellotte

doi:10.1001/archneur.1973.00490250019001

Papovavirus of JC Type in Progressive Multifocal Leukoencephalopathy: Rapid Identification and Subsequent Isolation

Leslie P. Weiner, Opendra Narayan, John B. Penney, Robert M. Herndon, Earl R. Feringa, Richard T. Johnson, Wallace W. Tourtellotte

School of Medicine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

A papovavirus of the JC type was identified in the brain of a patient dying of progressive multifocal leukoencephalopathy (PML) complicating chronic lymphocytic leukemia. Rapid antigenic typing of the virus was carried out by fluorescent antibody staining of the brain and by electron microscopic agglutination of virus particles extracted directly from the brain. Subsequently, the virus was isolated from brain tissue in primary cell cultures of human fetal brain. This second association of JC virus with PML confirms that at least two antigenically distinct viruses may cause PML and demonstrates that methods are now available for the rapid identification of the papovaviruses that may be related to the disease.

Original language	English (US)
Pages (from-to)	1-3
Number of pages	3
Journal	Archives of neurology
Volume	29
Issue number	1
DOIs	https://doi.org/10.1001/archneur.1973.00490250019001
State	Published - Jul 1973

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology

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abstract = "A papovavirus of the JC type was identified in the brain of a patient dying of progressive multifocal leukoencephalopathy (PML) complicating chronic lymphocytic leukemia. Rapid antigenic typing of the virus was carried out by fluorescent antibody staining of the brain and by electron microscopic agglutination of virus particles extracted directly from the brain. Subsequently, the virus was isolated from brain tissue in primary cell cultures of human fetal brain. This second association of JC virus with PML confirms that at least two antigenically distinct viruses may cause PML and demonstrates that methods are now available for the rapid identification of the papovaviruses that may be related to the disease.",

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AU - Narayan, Opendra

AU - Penney, John B.

AU - Herndon, Robert M.

AU - Feringa, Earl R.

AU - Johnson, Richard T.

AU - Tourtellotte, Wallace W.

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AB - A papovavirus of the JC type was identified in the brain of a patient dying of progressive multifocal leukoencephalopathy (PML) complicating chronic lymphocytic leukemia. Rapid antigenic typing of the virus was carried out by fluorescent antibody staining of the brain and by electron microscopic agglutination of virus particles extracted directly from the brain. Subsequently, the virus was isolated from brain tissue in primary cell cultures of human fetal brain. This second association of JC virus with PML confirms that at least two antigenically distinct viruses may cause PML and demonstrates that methods are now available for the rapid identification of the papovaviruses that may be related to the disease.

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Papovavirus of JC Type in Progressive Multifocal Leukoencephalopathy: Rapid Identification and Subsequent Isolation

Abstract

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