Papillomavirus E1 proteins: Form, function, and features

Van G. Wilson; Michael West; Kelly Woytek; Dandapani Rangasamy

doi:10.1023/A:1015336817836

Papillomavirus E1 proteins: Form, function, and features

Van G. Wilson, Michael West, Kelly Woytek, Dandapani Rangasamy

Research output: Contribution to journal › Review article › peer-review

92 Scopus citations

Abstract

The E1 proteins are the essential origin recognition proteins for papillomavirus (PV) replication. E1 proteins bind to specific DNA elements in the viral origin of replication and assemble into hexameric helicases with the aid of a second viral protein, E2. The resultant helicase complex initiates origin DNA unwinding to provide the template for subsequent syntheses of progeny DNA. In addition to ATP-dependent helicase activity, E1 proteins interact with and recruit several host cell replication proteins to viral origin, including DNA polymerase α and RPA. This review will compare the basic structures and features of the human (HPV) and bovine (BPV1) papillomaviruses with an emphasis on mechanisms of replication function.

Original language	English (US)
Pages (from-to)	275-290
Number of pages	16
Journal	Virus Genes
Volume	24
Issue number	3
DOIs	https://doi.org/10.1023/A:1015336817836
State	Published - 2002
Externally published	Yes

Keywords

DNA binding proteins
DNA replication
Helicase
Papovavirus

ASJC Scopus subject areas

Molecular Biology
Genetics
Virology

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10.1023/A:1015336817836

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abstract = "The E1 proteins are the essential origin recognition proteins for papillomavirus (PV) replication. E1 proteins bind to specific DNA elements in the viral origin of replication and assemble into hexameric helicases with the aid of a second viral protein, E2. The resultant helicase complex initiates origin DNA unwinding to provide the template for subsequent syntheses of progeny DNA. In addition to ATP-dependent helicase activity, E1 proteins interact with and recruit several host cell replication proteins to viral origin, including DNA polymerase α and RPA. This review will compare the basic structures and features of the human (HPV) and bovine (BPV1) papillomaviruses with an emphasis on mechanisms of replication function.",

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AU - Woytek, Kelly

AU - Rangasamy, Dandapani

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AB - The E1 proteins are the essential origin recognition proteins for papillomavirus (PV) replication. E1 proteins bind to specific DNA elements in the viral origin of replication and assemble into hexameric helicases with the aid of a second viral protein, E2. The resultant helicase complex initiates origin DNA unwinding to provide the template for subsequent syntheses of progeny DNA. In addition to ATP-dependent helicase activity, E1 proteins interact with and recruit several host cell replication proteins to viral origin, including DNA polymerase α and RPA. This review will compare the basic structures and features of the human (HPV) and bovine (BPV1) papillomaviruses with an emphasis on mechanisms of replication function.

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Papillomavirus E1 proteins: Form, function, and features

Abstract

Keywords

ASJC Scopus subject areas

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