Panorama of DNA hairpin folding observed via diffusion-decelerated fluorescence correlation spectroscopy

Yandong Yin, Peng Wang, Xin Xing Yang, Xun Li, Chuan He, Xin Sheng Zhao

Research output: Contribution to journalArticle

Abstract

Based on a confocal microscopy platform, we extended the FCS time window by three orders of magnitude to the s timescale by attaching a polystyrene microsphere. We simultaneously monitored the relaxations of multiple intermediates involved in DNA hairpin folding, thus offering a much more detailed view of the kinetics of hairpin folding experimentally.

Original languageEnglish (US)
Pages (from-to)7413-7415
Number of pages3
JournalChemical Communications
Volume48
Issue number59
DOIs
StatePublished - Jun 27 2012
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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