Panksepp’s SEEKING system concepts and their implications for the treatment of depression with deep-brain stimulation

Volker A. Coenen, Thomas E. Schlaepfer

Research output: Contribution to journalArticle

Abstract

Panksepp, as the true founder of the field of affective neuroscience, has predicted that the understanding of the emotional systems of animals will lead to understanding on the nature of human feelings. The Target Article that we comment on most convincingly shows a careful analysis of impaired SEEKING function for the clinical entity of major depression. It becomes increasingly clear that certain affective imbalances of this and other disorders (e.g., addiction) converge on a common subcortical emotional system, the very SEEKING system that Wright & Panksepp discuss. We conclude our comment with the first report of actual medial forebrain bundle (SEEKING system) stimulation results in humans, treated for therapy refractory depression and performed by our group.

Original languageEnglish (US)
Pages (from-to)43-45
Number of pages3
JournalNeuropsychoanalysis
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2012

Keywords

  • Appetitive motivation
  • Deep-brain stimulation
  • Depression
  • Diffusion tensor imaging
  • Reward system

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

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