PANDAS: A commentary

Harvey S. Singer, Christopher Loiselle

Research output: Contribution to journalArticlepeer-review


PANDAS is an acronym for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infection. As defined, the criteria include prepubertal children with either a tic or obsessive-compulsive disorder in whom a Group A β-hemolytic streptococcal infection (GABHS) triggers the abrupt onset or exacerbation of tics/obsessive-compulsive behaviors. Pathophysiologically, it is proposed that antibodies produced against GABHS cross-react with neuronal cells, in a process involving molecular mimicry. Although PANDAS has received widespread notoriety, the existence of this condition has been questioned. This commentary reviews clinical and laboratory issues pertinent to the diagnosis of this entity. We conclude that PANDAS is an intriguing hypothesis that requires further confirmation.

Original languageEnglish (US)
Pages (from-to)31-39
Number of pages9
JournalJournal of Psychosomatic Research
Issue number1
StatePublished - Jul 1 2003


  • Autoimmunity
  • Neuropsychiatric disorders
  • OCD
  • Streptococcal infection
  • Tics

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health


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