PANDAS

D. S. Wolf, H. S. Singer

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

PANDAS is the acronym for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infection. It requires an abrupt onset and repeat exacerbations of tics/obsessive-compulsive behaviors occurring in temporal association with a Group A β-hemolytic streptococcal infection (GABHS). Since its initial description, investigators have been actively seeking to confirm diagnostic criteria, validate the temporal association of GABHS, document abnormalities of immune markers, and establish an association between infection-related clinical exacerbation and alterations in the level of antineuronal antibodies or cytokines. Clinical and scientific investigations are useful to support or refute the diagnosis of PANDAS.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Movement Disorders
PublisherElsevier Inc.
Pages369-373
Number of pages5
ISBN (Electronic)9780123741059
ISBN (Print)9780123741011
DOIs
StatePublished - Jan 1 2010

Keywords

  • Antineuronal antibodies
  • Cytokines
  • Group A β-hemolytic streptococcal infection
  • OCD
  • PANDAS
  • Sydenham chorea
  • Tics
  • Tourette syndrome

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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