Pancreatic undifferentiated carcinoma with osteoclast-like giant cells is genetically similar to, but clinically distinct from, conventional ductal adenocarcinoma

Claudio Luchini, Antonio Pea, Gemma Lionheart, Andrea Mafficini, Alessia Nottegar, Nicola Veronese, Peter Chianchiano, Lodewijk A.A. Brosens, Michaël Noë, G. Johan A. Offerhaus, Raluca Yonescu, Yi Ning, Giuseppe Malleo, Giulio Riva, Paola Piccoli, Ivana Cataldo, Paola Capelli, Giuseppe Zamboni, Aldo Scarpa, Laura D. Wood

Research output: Contribution to journalArticle

Abstract

Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UCOGC) is currently considered a morphologically and clinically distinct variant of pancreatic ductal adenocarcinoma (PDAC). In this study, we report clinical and pathological features of a series of 22 UCOGCs, including the whole exome sequencing of eight UCOGCs. We observed that 60% of the UCOGCs contained a well-defined epithelial component and that patients with pure UCOGC had a significantly better prognosis than did those with an UCOGC with an associated epithelial neoplasm. The genetic alterations in UCOGC are strikingly similar to those known to drive conventional PDAC, including activating mutations in the oncogene KRAS and inactivating mutations in the tumor suppressor genes CDKN2A, TP53, and SMAD4. These results further support the classification of UCOGC as a PDAC variant and suggest that somatic mutations are not the determinants of the unique phenotype of UCOGC.

Original languageEnglish (US)
Pages (from-to)148-154
Number of pages7
JournalJournal of Pathology
Volume243
Issue number2
DOIs
StatePublished - Oct 2017

Keywords

  • PDAC variants
  • undifferentiated carcinoma with osteoclast-like giant cells
  • whole exome sequencing

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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  • Cite this

    Luchini, C., Pea, A., Lionheart, G., Mafficini, A., Nottegar, A., Veronese, N., Chianchiano, P., Brosens, L. A. A., Noë, M., Offerhaus, G. J. A., Yonescu, R., Ning, Y., Malleo, G., Riva, G., Piccoli, P., Cataldo, I., Capelli, P., Zamboni, G., Scarpa, A., & Wood, L. D. (2017). Pancreatic undifferentiated carcinoma with osteoclast-like giant cells is genetically similar to, but clinically distinct from, conventional ductal adenocarcinoma. Journal of Pathology, 243(2), 148-154. https://doi.org/10.1002/path.4941