TY - JOUR
T1 - Pancreatic Polypeptide-Producing Tumors
T2 - Silent Lesions of the Pancreas?
AU - Strodel, William E.
AU - Vinik, Aaron I.
AU - Lloyd, Ricardo V.
AU - Glaser, Benjamin
AU - Eckhauser, Frederic E.
AU - Fiddian-Green, Richard G.
AU - Turcotte, Jeremiah G.
AU - Thompson, Norman W.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1984/5
Y1 - 1984/5
N2 - Eight patients with pancreatic polypeptide (PP)-producing islet cell tumors and one patient with pseudo-pp-producing tumors were examined. Their age range was 20 to 74 years. Clinical features included abdominal pain in four patients, weight loss in four patients, diarrhea in two patients, gastrointestinal bleeding in two patients, and jaundice in one patient. The range of the basal serum level of PP was 394 to 35,100 pg/mL. In two patients the PP-producing tumors were associated with multiple endocrine neoplasia. Two patients had diffuse hepatic metastases at the time of diagnosis and four patients had disease limited to the pancreas. Pancreaticoduodenectomy and 80% pancreatectomy were performed in four and two patients, respectively. Immunohistochemical staining was positive for PP and neuron-specific enolase in all cases and was negative for other peptides except in one specimen with microadenomatosis. Patients who underwent curative resection are asymptomatic with normal serum levels of PP.
AB - Eight patients with pancreatic polypeptide (PP)-producing islet cell tumors and one patient with pseudo-pp-producing tumors were examined. Their age range was 20 to 74 years. Clinical features included abdominal pain in four patients, weight loss in four patients, diarrhea in two patients, gastrointestinal bleeding in two patients, and jaundice in one patient. The range of the basal serum level of PP was 394 to 35,100 pg/mL. In two patients the PP-producing tumors were associated with multiple endocrine neoplasia. Two patients had diffuse hepatic metastases at the time of diagnosis and four patients had disease limited to the pancreas. Pancreaticoduodenectomy and 80% pancreatectomy were performed in four and two patients, respectively. Immunohistochemical staining was positive for PP and neuron-specific enolase in all cases and was negative for other peptides except in one specimen with microadenomatosis. Patients who underwent curative resection are asymptomatic with normal serum levels of PP.
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U2 - 10.1001/archsurg.1984.01390170008003
DO - 10.1001/archsurg.1984.01390170008003
M3 - Article
C2 - 6143548
AN - SCOPUS:0021319623
SN - 0004-0010
VL - 119
SP - 508
EP - 514
JO - Archives of surgery
JF - Archives of surgery
IS - 5
ER -