Pancreatic Endocrine Insufficiency in Posttransplant Cystinosis

Barbara Fivush, Orville C. Green, Craig C. Porter, J. Williamson Balfe, Sean O'regan, William A. Gahl

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Nephropathlc cystinosis causes renal death by approximately age 10 years. With increased life span due to kidney transplantation, ten to 25 years of cystine accumulation has resulted in pancreatic complications in individuals with cystinosis. We noted severe hyperglycemia in five posttransplant patients, three of whom remained insulin-dependent diabetics several years after transPlant. The clinical findings were not consistent with steroid-dependent or insulin-resistant diabetes. Pancreatic cystine deposition was detected histologically and biochemically on postmortem examination of two other patients. We conclude that hyperglycemia may be anticipated in the immediate posttransplant period in cystinotic patients and that some patients will require insulin therapy years later. The use of cystine-depleting agents should be considered in posttransplant cystinosis as an attempt to prevent potential damage to the pancreas and other organs from cystine deposition.

Original languageEnglish (US)
Pages (from-to)1087-1089
Number of pages3
JournalAmerican Journal of Diseases of Children
Issue number10
StatePublished - Oct 1987

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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