Pancreatic carcinoma versus chronic pancreatitis: Dynamic MR imaging

Pamela Johnson, Eric K. Outwater

Research output: Contribution to journalArticle

Abstract

PURPOSE: To determine if dynamic gadolinium-enhanced magnetic resonance (MR) imaging can distinguish chronic pancreatitis from pancreatic carcinoma. MATERIALS AND METHODS: A retrospective review of MR and pathology examination findings was performed for 24 patients with pancreatic ductal adenocarcinoma and seven with chronic pancreatitis who underwent gadolinium-enhanced-hold spoiled gradient-echo imaging. Arterial, portal, and delayed phase images were obtained after injection of gadopentatate dimeglumine. The MR images of 14 patients without clinical evidence of pancreatic disease were also reviewed as controls. Signal intensity (SI) was measured on the precontrast (pre) and gadolinium-enhanced (post) images of the area of the pancreas sampled at biopsy and of the nontumorous pancreas. Percentage enhancement was defined as SI(pre)/SI(post) x 100. RESULTS. Normal pancreas showed rapid enhancement that peaked in the arterial or portal phase. For both diseases, T1-weighted images showed hypointense masses with progressive enhancement (differences were significant [P <.05] on only delayed fat-saturated images). Differences in enhancement between either disease state and normal pancreas were significant at least one phase. Nontumorous pancreas in patients with carcinoma showed gradual enhancement that was significantly different from that of normal pancreas. CONCLUSION: Chronic pancreatitis and pancreatic carcinoma show abnormal pancreatic enhancement, but the two were not distinguished on the basis of degree and time of enhancement.

Original languageEnglish (US)
Pages (from-to)213-218
Number of pages6
JournalRadiology
Volume212
Issue number1
StatePublished - Jul 1999
Externally publishedYes

Fingerprint

Chronic Pancreatitis
Pancreas
Magnetic Resonance Imaging
Gadolinium
Magnetic Resonance Spectroscopy
Pancreatic Diseases
Pancreatic Carcinoma
Adenocarcinoma
Fats
Pathology
Carcinoma
Biopsy
Injections

Keywords

  • Pancreas, MR
  • Pancreas, neoplasms
  • Pancreatitis

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Pancreatic carcinoma versus chronic pancreatitis : Dynamic MR imaging. / Johnson, Pamela; Outwater, Eric K.

In: Radiology, Vol. 212, No. 1, 07.1999, p. 213-218.

Research output: Contribution to journalArticle

Johnson, Pamela ; Outwater, Eric K. / Pancreatic carcinoma versus chronic pancreatitis : Dynamic MR imaging. In: Radiology. 1999 ; Vol. 212, No. 1. pp. 213-218.
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