Pancreatic cancer risk and ABO blood group alleles: Results from the Pancreatic Cancer Cohort Consortium

Brian M. Wolpin, Peter Kraft, Myron Gross, Kathy Helzlsouer, H. Bas Bueno-de-Mesquita, Emily Steplowski, Rachael Z. Stolzenberg-Solomon, Alan A. Arslan, Eric J. Jacobs, Andrea LaCroix, Gloria Petersen, Wei Zheng, Demetrius Albanes, Naomi E. Allen, Laufey Amundadottir, Garnet Anderson, Marie Christine Boutron-Ruault, Julie E. Buring, Federico Canzian, Stephen J. ChanockSandra Clipp, John Michael Gaziano, Edward L. Giovannucci, Göran Hallmans, Susan E. Hankinson, Robert N. Hoover, David J. Hunter, Amy Hutchinson, Kevin Jacobs, Charles Kooperberg, Shannon M. Lynch, Julie B. Mendelsohn, Dominique S. Michaud, Kim Overvad, Alpa V. Patel, Aleksandar Rajkovic, Maria José Sanchéz, Xiao Ou Shu, Nadia Slimani, Gilles Thomas, Geoffrey S. Tobias, Dimitrios Trichopoulos, Paolo Vineis, Jarmo Virtamo, Jean Wactawski-Wende, Kai Yu, Anne Zeleniuch-Jacquotte, Patricia Hartge Charles S Fuchs

Research output: Contribution to journalArticle

Abstract

A recent genome-wide association study (PanScan) identified significant associations at the ABO gene locus with risk of pancreatic cancer, but the influence of specific ABO genotypes remains unknown. We determined ABO genotypes (OO, AO, AA, AB, BO, and BB) in 1,534 cases and 1,583 controls from 12 prospective cohorts in PanScan, grouping participants by genotype-derived serologic blood type (O, A, AB, and B). Adjusted odds ratios (ORs) for pancreatic cancer by ABO alleles were calculated using logistic regression. Compared with blood type O, the ORs for pancreatic cancer in subjects with types A, AB, and B were 1.38 [95% confidence interval (95% CI), 1.18-1.62], 1.47 (95% CI, 1.07-2.02), and 1.53 (95% CI, 1.21-1.92), respectively. The incidence rates for blood types O, A, AB, and B were 28.9, 39.9, 41.8, and 44.5 cases per 100,000 subjects per year. An increase in risk was noted with the addition of each non-O allele. Compared with OO genotype, subjects with AO and AA genotype had ORs of 1.33 (95% CI, 1.13-1.58) and 1.61 (95% CI, 1.22-2.18), whereas subjects with BO and BB genotypes had ORs of 1.45 (95% CI, 1.14-1.85) and 2.42 (1.28-4.57). The population attributable fraction for non-O blood type was 19.5%. In a joint model with smoking, current smokers with non-O blood type had an adjusted OR of 2.68 (95% CI, 2.03-3.54) compared with nonsmokers of blood type O. We concluded that ABO genotypes were significantly associated with pancreatic cancer risk.

Original languageEnglish (US)
Pages (from-to)1015-1023
Number of pages9
JournalCancer Research
Volume70
Issue number3
DOIs
StatePublished - Feb 1 2010

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Blood Group Antigens
Pancreatic Neoplasms
Alleles
Genotype
Confidence Intervals
Odds Ratio
Genome-Wide Association Study
Joints
Logistic Models
Smoking
Incidence
Population
Genes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Wolpin, B. M., Kraft, P., Gross, M., Helzlsouer, K., Bueno-de-Mesquita, H. B., Steplowski, E., ... Fuchs, P. H. C. S. (2010). Pancreatic cancer risk and ABO blood group alleles: Results from the Pancreatic Cancer Cohort Consortium. Cancer Research, 70(3), 1015-1023. https://doi.org/10.1158/0008-5472.CAN-09-2993

Pancreatic cancer risk and ABO blood group alleles : Results from the Pancreatic Cancer Cohort Consortium. / Wolpin, Brian M.; Kraft, Peter; Gross, Myron; Helzlsouer, Kathy; Bueno-de-Mesquita, H. Bas; Steplowski, Emily; Stolzenberg-Solomon, Rachael Z.; Arslan, Alan A.; Jacobs, Eric J.; LaCroix, Andrea; Petersen, Gloria; Zheng, Wei; Albanes, Demetrius; Allen, Naomi E.; Amundadottir, Laufey; Anderson, Garnet; Boutron-Ruault, Marie Christine; Buring, Julie E.; Canzian, Federico; Chanock, Stephen J.; Clipp, Sandra; Gaziano, John Michael; Giovannucci, Edward L.; Hallmans, Göran; Hankinson, Susan E.; Hoover, Robert N.; Hunter, David J.; Hutchinson, Amy; Jacobs, Kevin; Kooperberg, Charles; Lynch, Shannon M.; Mendelsohn, Julie B.; Michaud, Dominique S.; Overvad, Kim; Patel, Alpa V.; Rajkovic, Aleksandar; Sanchéz, Maria José; Shu, Xiao Ou; Slimani, Nadia; Thomas, Gilles; Tobias, Geoffrey S.; Trichopoulos, Dimitrios; Vineis, Paolo; Virtamo, Jarmo; Wactawski-Wende, Jean; Yu, Kai; Zeleniuch-Jacquotte, Anne; Fuchs, Patricia Hartge Charles S.

In: Cancer Research, Vol. 70, No. 3, 01.02.2010, p. 1015-1023.

Research output: Contribution to journalArticle

Wolpin, BM, Kraft, P, Gross, M, Helzlsouer, K, Bueno-de-Mesquita, HB, Steplowski, E, Stolzenberg-Solomon, RZ, Arslan, AA, Jacobs, EJ, LaCroix, A, Petersen, G, Zheng, W, Albanes, D, Allen, NE, Amundadottir, L, Anderson, G, Boutron-Ruault, MC, Buring, JE, Canzian, F, Chanock, SJ, Clipp, S, Gaziano, JM, Giovannucci, EL, Hallmans, G, Hankinson, SE, Hoover, RN, Hunter, DJ, Hutchinson, A, Jacobs, K, Kooperberg, C, Lynch, SM, Mendelsohn, JB, Michaud, DS, Overvad, K, Patel, AV, Rajkovic, A, Sanchéz, MJ, Shu, XO, Slimani, N, Thomas, G, Tobias, GS, Trichopoulos, D, Vineis, P, Virtamo, J, Wactawski-Wende, J, Yu, K, Zeleniuch-Jacquotte, A & Fuchs, PHCS 2010, 'Pancreatic cancer risk and ABO blood group alleles: Results from the Pancreatic Cancer Cohort Consortium', Cancer Research, vol. 70, no. 3, pp. 1015-1023. https://doi.org/10.1158/0008-5472.CAN-09-2993
Wolpin BM, Kraft P, Gross M, Helzlsouer K, Bueno-de-Mesquita HB, Steplowski E et al. Pancreatic cancer risk and ABO blood group alleles: Results from the Pancreatic Cancer Cohort Consortium. Cancer Research. 2010 Feb 1;70(3):1015-1023. https://doi.org/10.1158/0008-5472.CAN-09-2993
Wolpin, Brian M. ; Kraft, Peter ; Gross, Myron ; Helzlsouer, Kathy ; Bueno-de-Mesquita, H. Bas ; Steplowski, Emily ; Stolzenberg-Solomon, Rachael Z. ; Arslan, Alan A. ; Jacobs, Eric J. ; LaCroix, Andrea ; Petersen, Gloria ; Zheng, Wei ; Albanes, Demetrius ; Allen, Naomi E. ; Amundadottir, Laufey ; Anderson, Garnet ; Boutron-Ruault, Marie Christine ; Buring, Julie E. ; Canzian, Federico ; Chanock, Stephen J. ; Clipp, Sandra ; Gaziano, John Michael ; Giovannucci, Edward L. ; Hallmans, Göran ; Hankinson, Susan E. ; Hoover, Robert N. ; Hunter, David J. ; Hutchinson, Amy ; Jacobs, Kevin ; Kooperberg, Charles ; Lynch, Shannon M. ; Mendelsohn, Julie B. ; Michaud, Dominique S. ; Overvad, Kim ; Patel, Alpa V. ; Rajkovic, Aleksandar ; Sanchéz, Maria José ; Shu, Xiao Ou ; Slimani, Nadia ; Thomas, Gilles ; Tobias, Geoffrey S. ; Trichopoulos, Dimitrios ; Vineis, Paolo ; Virtamo, Jarmo ; Wactawski-Wende, Jean ; Yu, Kai ; Zeleniuch-Jacquotte, Anne ; Fuchs, Patricia Hartge Charles S. / Pancreatic cancer risk and ABO blood group alleles : Results from the Pancreatic Cancer Cohort Consortium. In: Cancer Research. 2010 ; Vol. 70, No. 3. pp. 1015-1023.
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abstract = "A recent genome-wide association study (PanScan) identified significant associations at the ABO gene locus with risk of pancreatic cancer, but the influence of specific ABO genotypes remains unknown. We determined ABO genotypes (OO, AO, AA, AB, BO, and BB) in 1,534 cases and 1,583 controls from 12 prospective cohorts in PanScan, grouping participants by genotype-derived serologic blood type (O, A, AB, and B). Adjusted odds ratios (ORs) for pancreatic cancer by ABO alleles were calculated using logistic regression. Compared with blood type O, the ORs for pancreatic cancer in subjects with types A, AB, and B were 1.38 [95{\%} confidence interval (95{\%} CI), 1.18-1.62], 1.47 (95{\%} CI, 1.07-2.02), and 1.53 (95{\%} CI, 1.21-1.92), respectively. The incidence rates for blood types O, A, AB, and B were 28.9, 39.9, 41.8, and 44.5 cases per 100,000 subjects per year. An increase in risk was noted with the addition of each non-O allele. Compared with OO genotype, subjects with AO and AA genotype had ORs of 1.33 (95{\%} CI, 1.13-1.58) and 1.61 (95{\%} CI, 1.22-2.18), whereas subjects with BO and BB genotypes had ORs of 1.45 (95{\%} CI, 1.14-1.85) and 2.42 (1.28-4.57). The population attributable fraction for non-O blood type was 19.5{\%}. In a joint model with smoking, current smokers with non-O blood type had an adjusted OR of 2.68 (95{\%} CI, 2.03-3.54) compared with nonsmokers of blood type O. We concluded that ABO genotypes were significantly associated with pancreatic cancer risk.",
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T1 - Pancreatic cancer risk and ABO blood group alleles

T2 - Results from the Pancreatic Cancer Cohort Consortium

AU - Wolpin, Brian M.

AU - Kraft, Peter

AU - Gross, Myron

AU - Helzlsouer, Kathy

AU - Bueno-de-Mesquita, H. Bas

AU - Steplowski, Emily

AU - Stolzenberg-Solomon, Rachael Z.

AU - Arslan, Alan A.

AU - Jacobs, Eric J.

AU - LaCroix, Andrea

AU - Petersen, Gloria

AU - Zheng, Wei

AU - Albanes, Demetrius

AU - Allen, Naomi E.

AU - Amundadottir, Laufey

AU - Anderson, Garnet

AU - Boutron-Ruault, Marie Christine

AU - Buring, Julie E.

AU - Canzian, Federico

AU - Chanock, Stephen J.

AU - Clipp, Sandra

AU - Gaziano, John Michael

AU - Giovannucci, Edward L.

AU - Hallmans, Göran

AU - Hankinson, Susan E.

AU - Hoover, Robert N.

AU - Hunter, David J.

AU - Hutchinson, Amy

AU - Jacobs, Kevin

AU - Kooperberg, Charles

AU - Lynch, Shannon M.

AU - Mendelsohn, Julie B.

AU - Michaud, Dominique S.

AU - Overvad, Kim

AU - Patel, Alpa V.

AU - Rajkovic, Aleksandar

AU - Sanchéz, Maria José

AU - Shu, Xiao Ou

AU - Slimani, Nadia

AU - Thomas, Gilles

AU - Tobias, Geoffrey S.

AU - Trichopoulos, Dimitrios

AU - Vineis, Paolo

AU - Virtamo, Jarmo

AU - Wactawski-Wende, Jean

AU - Yu, Kai

AU - Zeleniuch-Jacquotte, Anne

AU - Fuchs, Patricia Hartge Charles S

PY - 2010/2/1

Y1 - 2010/2/1

N2 - A recent genome-wide association study (PanScan) identified significant associations at the ABO gene locus with risk of pancreatic cancer, but the influence of specific ABO genotypes remains unknown. We determined ABO genotypes (OO, AO, AA, AB, BO, and BB) in 1,534 cases and 1,583 controls from 12 prospective cohorts in PanScan, grouping participants by genotype-derived serologic blood type (O, A, AB, and B). Adjusted odds ratios (ORs) for pancreatic cancer by ABO alleles were calculated using logistic regression. Compared with blood type O, the ORs for pancreatic cancer in subjects with types A, AB, and B were 1.38 [95% confidence interval (95% CI), 1.18-1.62], 1.47 (95% CI, 1.07-2.02), and 1.53 (95% CI, 1.21-1.92), respectively. The incidence rates for blood types O, A, AB, and B were 28.9, 39.9, 41.8, and 44.5 cases per 100,000 subjects per year. An increase in risk was noted with the addition of each non-O allele. Compared with OO genotype, subjects with AO and AA genotype had ORs of 1.33 (95% CI, 1.13-1.58) and 1.61 (95% CI, 1.22-2.18), whereas subjects with BO and BB genotypes had ORs of 1.45 (95% CI, 1.14-1.85) and 2.42 (1.28-4.57). The population attributable fraction for non-O blood type was 19.5%. In a joint model with smoking, current smokers with non-O blood type had an adjusted OR of 2.68 (95% CI, 2.03-3.54) compared with nonsmokers of blood type O. We concluded that ABO genotypes were significantly associated with pancreatic cancer risk.

AB - A recent genome-wide association study (PanScan) identified significant associations at the ABO gene locus with risk of pancreatic cancer, but the influence of specific ABO genotypes remains unknown. We determined ABO genotypes (OO, AO, AA, AB, BO, and BB) in 1,534 cases and 1,583 controls from 12 prospective cohorts in PanScan, grouping participants by genotype-derived serologic blood type (O, A, AB, and B). Adjusted odds ratios (ORs) for pancreatic cancer by ABO alleles were calculated using logistic regression. Compared with blood type O, the ORs for pancreatic cancer in subjects with types A, AB, and B were 1.38 [95% confidence interval (95% CI), 1.18-1.62], 1.47 (95% CI, 1.07-2.02), and 1.53 (95% CI, 1.21-1.92), respectively. The incidence rates for blood types O, A, AB, and B were 28.9, 39.9, 41.8, and 44.5 cases per 100,000 subjects per year. An increase in risk was noted with the addition of each non-O allele. Compared with OO genotype, subjects with AO and AA genotype had ORs of 1.33 (95% CI, 1.13-1.58) and 1.61 (95% CI, 1.22-2.18), whereas subjects with BO and BB genotypes had ORs of 1.45 (95% CI, 1.14-1.85) and 2.42 (1.28-4.57). The population attributable fraction for non-O blood type was 19.5%. In a joint model with smoking, current smokers with non-O blood type had an adjusted OR of 2.68 (95% CI, 2.03-3.54) compared with nonsmokers of blood type O. We concluded that ABO genotypes were significantly associated with pancreatic cancer risk.

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