Pancreatic cancer genomics

Insights and opportunities for clinical translation

Alvin Makohon-Moore, Jacqueline A. Brosnan, Christine A. Iacobuzio-Donahue

Research output: Contribution to journalArticle

Abstract

Pancreatic cancer is a highly lethal tumor type for which there are few viable therapeutic options. It is also caused by the accumulation of mutations in a variety of genes. These genetic alterations can be grouped into those that accumulate during pancreatic intraepithelial neoplasia (precursor lesions) and thus are present in all cells of the infiltrating carcinoma, and those that accumulate specifically within the infiltrating carcinoma during subclonal evolution, resulting in genetic heterogeneity. Despite this heterogeneity there are nonetheless commonly altered cellular functions, such as pathways controlling the cell cycle, DNA damage repair, intracellular signaling and development, which could provide for a variety of drug targets. This review aims to summarize current knowledge of the genetics and genomics of pancreatic cancer from its inception to metastatic colonization, and to provide examples of how this information can be translated into the clinical setting for therapeutic benefit and personalized medicine.

Original languageEnglish (US)
Article number26
JournalGenome Medicine
Volume5
Issue number3
DOIs
StatePublished - Mar 28 2013

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Genomics
Pancreatic Neoplasms
Carcinoma
Precision Medicine
Genetic Heterogeneity
DNA Repair
DNA Damage
Neoplasms
Cell Cycle
Therapeutics
Pharmaceutical Preparations
Genes
Mutation Accumulation

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics
  • Molecular Biology
  • Molecular Medicine

Cite this

Makohon-Moore, A., Brosnan, J. A., & Iacobuzio-Donahue, C. A. (2013). Pancreatic cancer genomics: Insights and opportunities for clinical translation. Genome Medicine, 5(3), [26]. https://doi.org/10.1186/gm430

Pancreatic cancer genomics : Insights and opportunities for clinical translation. / Makohon-Moore, Alvin; Brosnan, Jacqueline A.; Iacobuzio-Donahue, Christine A.

In: Genome Medicine, Vol. 5, No. 3, 26, 28.03.2013.

Research output: Contribution to journalArticle

Makohon-Moore, A, Brosnan, JA & Iacobuzio-Donahue, CA 2013, 'Pancreatic cancer genomics: Insights and opportunities for clinical translation', Genome Medicine, vol. 5, no. 3, 26. https://doi.org/10.1186/gm430
Makohon-Moore, Alvin ; Brosnan, Jacqueline A. ; Iacobuzio-Donahue, Christine A. / Pancreatic cancer genomics : Insights and opportunities for clinical translation. In: Genome Medicine. 2013 ; Vol. 5, No. 3.
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