Pancreatic adenocarcinoma: Update on the surgical pathology of carcinomas of ductal origin and panins

Ralph H. Hruban, Noriyoshi Fukushima

Research output: Contribution to journalArticle

Abstract

Pancreatic cancer is the fourth leading cause of cancer death in the US. Most pancreatic cancers are infiltrating ductal adenocarcinomas. The careful application of well-defined morphologic criteria can be used to differentiate between infiltrating ductal adenocarcinoma and reactive glands. While most pancreatic cancers are ductal adenocarcinomas, a number of histologically defined variants have been described. These are important to recognize because they have distinct clinical pathologic features. Pancreatic intraepithelial neoplasia (PanIN) is the presumed precursor lesion to infiltrating ductal adenocarcinoma, and PanIN lesions can mimic infiltrating cancer.

Original languageEnglish (US)
Pages (from-to)61-70
Number of pages10
JournalModern Pathology
Volume20
Issue number1
DOIs
StatePublished - Feb 2007

Keywords

  • Pancreas
  • Pancreatic cancer
  • Pancreatic intraepithelial neoplasia
  • Precursor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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