Pallidal activity during dystonia: Somatosensory reorganisation and changes with severity

Frederick Lenz, Jose Suarez, L. V. Metman, S. G. Reich, B. I. Karp, M. Hallett, L. H. Rowland, P. M. Dougherty

Research output: Contribution to journalArticle

Abstract

A woman with progressive, medically intractable right upper limb dystonia underwent a pallidotomy with only transient improvement. During the procedure her dystonia became more severe as she repeatedly made a fist to command in order to provoke dystonia transiently (movement provoked dystonia). Comparisons within cells in the internal segment of the globus pallidus (Gpi) disclosed that the firing rate was the same at rest, with making a fist, and during movement provoked dystonia. However, the firing rate compared between cells decreased significantly throughout the procedure as the patient made a fist repeatedly. During the second half of the procedure the firing rate of cells in the Gpi was similar to that in hemiballismus. The proportion of cells in the GPi which responded to sensory stimulation was significantly higher in dystonia (53%) than in hemiballismus (13%). These results suggest that pallidal activity can correlate inversely with the severity of dystonia, perhaps due to activity dependent changes in neuronal function resulting from repeated voluntary movement.

Original languageEnglish (US)
Pages (from-to)767-770
Number of pages4
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume65
Issue number5
StatePublished - 1998

Fingerprint

Dystonia
Globus Pallidus
Dyskinesias
Pallidotomy
Upper Extremity

Keywords

  • Apomorphine
  • Dystonia
  • Globus pallidus
  • Parkinson's disease
  • Plasticity

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Lenz, F., Suarez, J., Metman, L. V., Reich, S. G., Karp, B. I., Hallett, M., ... Dougherty, P. M. (1998). Pallidal activity during dystonia: Somatosensory reorganisation and changes with severity. Journal of Neurology Neurosurgery and Psychiatry, 65(5), 767-770.

Pallidal activity during dystonia : Somatosensory reorganisation and changes with severity. / Lenz, Frederick; Suarez, Jose; Metman, L. V.; Reich, S. G.; Karp, B. I.; Hallett, M.; Rowland, L. H.; Dougherty, P. M.

In: Journal of Neurology Neurosurgery and Psychiatry, Vol. 65, No. 5, 1998, p. 767-770.

Research output: Contribution to journalArticle

Lenz, F, Suarez, J, Metman, LV, Reich, SG, Karp, BI, Hallett, M, Rowland, LH & Dougherty, PM 1998, 'Pallidal activity during dystonia: Somatosensory reorganisation and changes with severity', Journal of Neurology Neurosurgery and Psychiatry, vol. 65, no. 5, pp. 767-770.
Lenz, Frederick ; Suarez, Jose ; Metman, L. V. ; Reich, S. G. ; Karp, B. I. ; Hallett, M. ; Rowland, L. H. ; Dougherty, P. M. / Pallidal activity during dystonia : Somatosensory reorganisation and changes with severity. In: Journal of Neurology Neurosurgery and Psychiatry. 1998 ; Vol. 65, No. 5. pp. 767-770.
@article{72040b8a91094496bc8e2640bc7a5a6d,
title = "Pallidal activity during dystonia: Somatosensory reorganisation and changes with severity",
abstract = "A woman with progressive, medically intractable right upper limb dystonia underwent a pallidotomy with only transient improvement. During the procedure her dystonia became more severe as she repeatedly made a fist to command in order to provoke dystonia transiently (movement provoked dystonia). Comparisons within cells in the internal segment of the globus pallidus (Gpi) disclosed that the firing rate was the same at rest, with making a fist, and during movement provoked dystonia. However, the firing rate compared between cells decreased significantly throughout the procedure as the patient made a fist repeatedly. During the second half of the procedure the firing rate of cells in the Gpi was similar to that in hemiballismus. The proportion of cells in the GPi which responded to sensory stimulation was significantly higher in dystonia (53{\%}) than in hemiballismus (13{\%}). These results suggest that pallidal activity can correlate inversely with the severity of dystonia, perhaps due to activity dependent changes in neuronal function resulting from repeated voluntary movement.",
keywords = "Apomorphine, Dystonia, Globus pallidus, Parkinson's disease, Plasticity",
author = "Frederick Lenz and Jose Suarez and Metman, {L. V.} and Reich, {S. G.} and Karp, {B. I.} and M. Hallett and Rowland, {L. H.} and Dougherty, {P. M.}",
year = "1998",
language = "English (US)",
volume = "65",
pages = "767--770",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "5",

}

TY - JOUR

T1 - Pallidal activity during dystonia

T2 - Somatosensory reorganisation and changes with severity

AU - Lenz, Frederick

AU - Suarez, Jose

AU - Metman, L. V.

AU - Reich, S. G.

AU - Karp, B. I.

AU - Hallett, M.

AU - Rowland, L. H.

AU - Dougherty, P. M.

PY - 1998

Y1 - 1998

N2 - A woman with progressive, medically intractable right upper limb dystonia underwent a pallidotomy with only transient improvement. During the procedure her dystonia became more severe as she repeatedly made a fist to command in order to provoke dystonia transiently (movement provoked dystonia). Comparisons within cells in the internal segment of the globus pallidus (Gpi) disclosed that the firing rate was the same at rest, with making a fist, and during movement provoked dystonia. However, the firing rate compared between cells decreased significantly throughout the procedure as the patient made a fist repeatedly. During the second half of the procedure the firing rate of cells in the Gpi was similar to that in hemiballismus. The proportion of cells in the GPi which responded to sensory stimulation was significantly higher in dystonia (53%) than in hemiballismus (13%). These results suggest that pallidal activity can correlate inversely with the severity of dystonia, perhaps due to activity dependent changes in neuronal function resulting from repeated voluntary movement.

AB - A woman with progressive, medically intractable right upper limb dystonia underwent a pallidotomy with only transient improvement. During the procedure her dystonia became more severe as she repeatedly made a fist to command in order to provoke dystonia transiently (movement provoked dystonia). Comparisons within cells in the internal segment of the globus pallidus (Gpi) disclosed that the firing rate was the same at rest, with making a fist, and during movement provoked dystonia. However, the firing rate compared between cells decreased significantly throughout the procedure as the patient made a fist repeatedly. During the second half of the procedure the firing rate of cells in the Gpi was similar to that in hemiballismus. The proportion of cells in the GPi which responded to sensory stimulation was significantly higher in dystonia (53%) than in hemiballismus (13%). These results suggest that pallidal activity can correlate inversely with the severity of dystonia, perhaps due to activity dependent changes in neuronal function resulting from repeated voluntary movement.

KW - Apomorphine

KW - Dystonia

KW - Globus pallidus

KW - Parkinson's disease

KW - Plasticity

UR - http://www.scopus.com/inward/record.url?scp=0031790892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031790892&partnerID=8YFLogxK

M3 - Article

C2 - 9810954

AN - SCOPUS:0031790892

VL - 65

SP - 767

EP - 770

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 5

ER -