Palliative care and phase 1 trials: Intervention to improve quality of life and provide education

Betty R. Ferrell, Vincent Chung, Marianna Koczywas, Anna Cathy Williams, Denise Gallagher, Patricia Fischer, Thomas J. Smith

Research output: Contribution to journalArticlepeer-review


Background: Patients in phase 1 clinical trials often have significant symptom burdens and quality-of-life concerns that increase as they progress along the cancer trajectory and experience drug toxicities from the clinical trial. Objectives: The interdisciplinary intervention described is aimed at providing optimum palliative care to support patients with solid tumors participating in a phase 1 clinical trial. Methods: The intervention includes a baseline evaluation using quantitative surveys, a comprehensive palliative care assessment by a research nurse based on patient baseline evaluation, and a goals-of-care discussion by the treating oncologist. The second component includes an interdisciplinary meeting where palliative care recommendations are made, followed by two patient education sessions. Findings: The initial experience with the palliative care intervention suggests a need for support for this population, as well as potential benefits from integrating palliative care for patients enrolled in phase 1 clinical trials.

Original languageEnglish (US)
Pages (from-to)473-479
Number of pages7
JournalClinical journal of oncology nursing
Issue number4
StatePublished - 2017


  • Palliative care
  • Phase 1 clinical trials
  • Quality of life
  • Symptom burden

ASJC Scopus subject areas

  • Oncology
  • Oncology(nursing)


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