TY - JOUR
T1 - Palettes of vaccines and immunostimulatory monoclonal antibodies for combination
AU - Melero, Ignacio
AU - Martinez-Forero, Ivan
AU - Dubrot, Juan
AU - Suarez, Natalia
AU - Palazón, Asis
AU - Chen, Lieping
PY - 2009/3/1
Y1 - 2009/3/1
N2 - Various monoclonal antibodies (mAb) target immune system molecules to enhance immunity by costimulating T cells (i.e., CD137, OX40, CD40, GITR) or interfering in coinhibitory signals (i.e., CTLA-4, PD-1). These powerful agents can be guided by cancer vaccines to enhance immunity against tumor but not self tissues. Clinically powerful therapeutic synergies are at hand.
AB - Various monoclonal antibodies (mAb) target immune system molecules to enhance immunity by costimulating T cells (i.e., CD137, OX40, CD40, GITR) or interfering in coinhibitory signals (i.e., CTLA-4, PD-1). These powerful agents can be guided by cancer vaccines to enhance immunity against tumor but not self tissues. Clinically powerful therapeutic synergies are at hand.
UR - http://www.scopus.com/inward/record.url?scp=63449088194&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=63449088194&partnerID=8YFLogxK
U2 - 10.1158/1078-0432.CCR-08-2931
DO - 10.1158/1078-0432.CCR-08-2931
M3 - Article
C2 - 19240168
AN - SCOPUS:63449088194
SN - 1078-0432
VL - 15
SP - 1507
EP - 1509
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 5
ER -