Palettes of vaccines and immunostimulatory monoclonal antibodies for combination

Ignacio Melero, Ivan Martinez-Forero, Juan Dubrot, Natalia Suarez, Asis Palazón, Lieping Chen

Research output: Contribution to journalArticle

Abstract

Various monoclonal antibodies (mAb) target immune system molecules to enhance immunity by costimulating T cells (i.e., CD137, OX40, CD40, GITR) or interfering in coinhibitory signals (i.e., CTLA-4, PD-1). These powerful agents can be guided by cancer vaccines to enhance immunity against tumor but not self tissues. Clinically powerful therapeutic synergies are at hand.

Original languageEnglish (US)
Pages (from-to)1507-1509
Number of pages3
JournalClinical Cancer Research
Volume15
Issue number5
DOIs
StatePublished - Mar 1 2009

    Fingerprint

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Melero, I., Martinez-Forero, I., Dubrot, J., Suarez, N., Palazón, A., & Chen, L. (2009). Palettes of vaccines and immunostimulatory monoclonal antibodies for combination. Clinical Cancer Research, 15(5), 1507-1509. https://doi.org/10.1158/1078-0432.CCR-08-2931