Palatable food avoidance and acceptance learning with different stressors in female rats

N. C. Liang, M. E. Smith, Timothy H Moran

Research output: Contribution to journalArticle

Abstract

Stress activates the hypothalamus-pituitary-adrenal (HPA) axis leading to the release of glucocorticoids (GC). Increased activity of the HPA axis and GC exposure has been suggested to facilitate the development of obesity and metabolic syndrome. Nonetheless, different stressors can produce distinct effects on food intake and may support different directions of food learning e.g. avoidance or acceptance. This study examined whether interoceptive (LiCl and exendin-4) and restraint stress (RS) support similar or distinct food learning. Female rats were exposed to different stressors after their consumption of a palatable food (butter icing). After four palatable food-stress pairings, distinct intakes of the butter icing were observed in rats treated with different stressors. Rats that received butter icing followed by intraperitoneal injections of LiCl (42.3. mg/kg) and exendin-4 (10 μg/kg) completely avoided the palatable food with subsequent presentations. In contrast, rats experiencing RS paired with the palatable food increased their consumption of butter icing across trials and did so to a greater degree than rats receiving saline injections. These data indicate that interoceptive and psychosocial stressors support conditioned food avoidance and acceptance, respectively. Examination of c-Fos immunoreactivity revealed distinct neural activation by interoceptive and psychosocial stressors that could provide the neural basis underlying opposite direction of food acceptance learning.

Original languageEnglish (US)
Pages (from-to)149-158
Number of pages10
JournalNeuroscience
Volume235
DOIs
StatePublished - Apr 3 2013

Fingerprint

Avoidance Learning
Food
Butter
Glucocorticoids
Hypothalamus
Learning
Intraperitoneal Injections
Obesity
Eating
Injections

Keywords

  • Binge eating
  • Food preference learning
  • HPA axis
  • Interoceptive stress
  • Restraint stress
  • Visceral pathway

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Palatable food avoidance and acceptance learning with different stressors in female rats. / Liang, N. C.; Smith, M. E.; Moran, Timothy H.

In: Neuroscience, Vol. 235, 03.04.2013, p. 149-158.

Research output: Contribution to journalArticle

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