Painful stimuli evoke potentials recorded over the human anterior cingulate gyrus

Lenz, Rios, Zirh, Chau, Krauss, Lesser

Research output: Contribution to journalArticle

Abstract

Clinical studies of cingulotomy patients and imaging studies predict that the human cingulate gyms might display pain-related activity. We now report potentials evoked by painful cutaneous stimulation with a CO2 laser (LEP) and recorded from subdural electrodes over the medial wall of the hemisphere. In response to facial laser stimulation on both sides, a negative (latency 211-242 ms) and then a positive wave (325-352 ms) were recorded from the cortex of right medial wall and from the falcine dura overlying the left medial wall. Medial wall LEPs were similar to scalp LEPs and were largest over the anterior cingulate and superior frontal gyri just anterior to motor cortex contralateral to the side of stimulation. These results demonstrate that there is significant direct nociceptive input to the human anterior cingulate gyms (Brodmann's area 24).

Original languageEnglish (US)
Pages (from-to)2231-2234
Number of pages4
JournalJournal of neurophysiology
Volume79
Issue number4
DOIs
StatePublished - Apr 1998

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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