Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction

Jeffrey S. Mogil, Robert E. Sorge, Michael L. Lacroix-Fralish, Shad B. Smith, Anny Fortin, Susana G. Sotocinal, Jennifer Ritchie, Jean Sebastien Austin, Ara Schorscher-Petcu, Kara Melmed, Jan Czerminski, Rosalie A. Bittong, J. Brad Mokris, John K. Neubert, Claudia Campbell, Robert R. Edwards, James N Campbell, Jacqueline N. Crawley, William R. Lariviere, Margaret R. Wallace & 4 others Wendy F. Sternberg, Carey D. Balaban, Inna Belfer, Roger B. Fillingim

Research output: Contribution to journalArticle

Abstract

Quantitative trait locus mapping of chemical/inflammatory pain in the mouse identified the Avpr1a gene, which encodes the vasopressin-1A receptor (V1AR), as being responsible for strain-dependent pain sensitivity to formalin and capsaicin. A genetic association study in humans revealed the influence of a single nucleotide polymorphism (rs10877969) in AVPR1A on capsaicin pain levels, but only in male subjects reporting stress at the time of testing. The analgesic efficacy of the vasopressin analog desmopressin revealed a similar interaction between the drug and acute stress, as desmopressin inhibition of capsaicin pain was only observed in nonstressed subjects. Additional experiments in mice confirmed the male-specific interaction of V1AR and stress, leading to the conclusion that vasopressin activates endogenous analgesia mechanisms unless they have already been activated by stress. These findings represent, to the best of our knowledge, the first explicit demonstration of analgesic efficacy depending on the emotional state of the recipient, and illustrate the heuristic power of a bench-to-bedside-to-bench translational strategy.

Original languageEnglish (US)
Pages (from-to)1569-1573
Number of pages5
JournalNature Neuroscience
Volume14
Issue number12
DOIs
StatePublished - Dec 2011

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Gene-Environment Interaction
Vasopressins
Analgesia
Capsaicin
Pain
Deamino Arginine Vasopressin
Vasopressin Receptors
Analgesics
Quantitative Trait Loci
Genetic Association Studies
Drug Interactions
Formaldehyde
Single Nucleotide Polymorphism
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mogil, J. S., Sorge, R. E., Lacroix-Fralish, M. L., Smith, S. B., Fortin, A., Sotocinal, S. G., ... Fillingim, R. B. (2011). Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction. Nature Neuroscience, 14(12), 1569-1573. https://doi.org/10.1038/nn.2941

Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction. / Mogil, Jeffrey S.; Sorge, Robert E.; Lacroix-Fralish, Michael L.; Smith, Shad B.; Fortin, Anny; Sotocinal, Susana G.; Ritchie, Jennifer; Austin, Jean Sebastien; Schorscher-Petcu, Ara; Melmed, Kara; Czerminski, Jan; Bittong, Rosalie A.; Mokris, J. Brad; Neubert, John K.; Campbell, Claudia; Edwards, Robert R.; Campbell, James N; Crawley, Jacqueline N.; Lariviere, William R.; Wallace, Margaret R.; Sternberg, Wendy F.; Balaban, Carey D.; Belfer, Inna; Fillingim, Roger B.

In: Nature Neuroscience, Vol. 14, No. 12, 12.2011, p. 1569-1573.

Research output: Contribution to journalArticle

Mogil, JS, Sorge, RE, Lacroix-Fralish, ML, Smith, SB, Fortin, A, Sotocinal, SG, Ritchie, J, Austin, JS, Schorscher-Petcu, A, Melmed, K, Czerminski, J, Bittong, RA, Mokris, JB, Neubert, JK, Campbell, C, Edwards, RR, Campbell, JN, Crawley, JN, Lariviere, WR, Wallace, MR, Sternberg, WF, Balaban, CD, Belfer, I & Fillingim, RB 2011, 'Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction', Nature Neuroscience, vol. 14, no. 12, pp. 1569-1573. https://doi.org/10.1038/nn.2941
Mogil JS, Sorge RE, Lacroix-Fralish ML, Smith SB, Fortin A, Sotocinal SG et al. Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction. Nature Neuroscience. 2011 Dec;14(12):1569-1573. https://doi.org/10.1038/nn.2941
Mogil, Jeffrey S. ; Sorge, Robert E. ; Lacroix-Fralish, Michael L. ; Smith, Shad B. ; Fortin, Anny ; Sotocinal, Susana G. ; Ritchie, Jennifer ; Austin, Jean Sebastien ; Schorscher-Petcu, Ara ; Melmed, Kara ; Czerminski, Jan ; Bittong, Rosalie A. ; Mokris, J. Brad ; Neubert, John K. ; Campbell, Claudia ; Edwards, Robert R. ; Campbell, James N ; Crawley, Jacqueline N. ; Lariviere, William R. ; Wallace, Margaret R. ; Sternberg, Wendy F. ; Balaban, Carey D. ; Belfer, Inna ; Fillingim, Roger B. / Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction. In: Nature Neuroscience. 2011 ; Vol. 14, No. 12. pp. 1569-1573.
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