Pain management in the Ehlers–Danlos syndromes

Pradeep Chopra, Brad Tinkle, Claude Hamonet, Isabelle Brock, Anne Gompel, Antonio Bulbena, Clair Ann Francomano

Research output: Contribution to journalReview article

Abstract

Chronic pain in the Ehlers–Danlos syndromes (EDS) is common and may be severe. According to one study, nearly 90% of patients report some form of chronic pain. Pain, which is often one of the first symptoms to occur, may be widespread or localized to one region such as an arm or a leg. Studies on treatment modalities are few and insufficient to guide management. The following is a discussion of the evidence regarding the underlying mechanisms of pain in EDS. The causes of pain in this condition are multifactorial and include joint subluxations and dislocations, previous surgery, muscle weakness, proprioceptive disorders, and vertebral instability. Affected persons may also present with generalized body pain, fatigue, headaches, gastrointestinal pain, temporomandibular joint pain, dysmenorrhea, and vulvodynia. Pain management strategies may be focused around treating the cause of the pain (e.g., dislocation of a joint, proprioceptive disorder) and minimizing the sensation of pain. Management strategies for chronic pain in EDS includes physical therapy, medications, as well as durable medical equipment such as cushions, compressive garments, and braces. The different modalities are discussed in this paper.

Original languageEnglish (US)
Pages (from-to)212-219
Number of pages8
JournalAmerican Journal of Medical Genetics, Part C: Seminars in Medical Genetics
Volume175
Issue number1
DOIs
StatePublished - Mar 1 2017

Fingerprint

Pain Management
Pain
Somatosensory Disorders
Joint Dislocations
Chronic Pain
Durable Medical Equipment
Vulvodynia
Dysmenorrhea
Braces
Clothing
Temporomandibular Joint
Muscle Weakness
Arthralgia
Fatigue
Headache
Leg
Arm
Therapeutics

Keywords

  • Ehlers–Danlos syndrome
  • hypermobility
  • joint pain
  • neuropathic
  • pain
  • pelvic pain
  • proprioception

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Pain management in the Ehlers–Danlos syndromes. / Chopra, Pradeep; Tinkle, Brad; Hamonet, Claude; Brock, Isabelle; Gompel, Anne; Bulbena, Antonio; Francomano, Clair Ann.

In: American Journal of Medical Genetics, Part C: Seminars in Medical Genetics, Vol. 175, No. 1, 01.03.2017, p. 212-219.

Research output: Contribution to journalReview article

Chopra, Pradeep ; Tinkle, Brad ; Hamonet, Claude ; Brock, Isabelle ; Gompel, Anne ; Bulbena, Antonio ; Francomano, Clair Ann. / Pain management in the Ehlers–Danlos syndromes. In: American Journal of Medical Genetics, Part C: Seminars in Medical Genetics. 2017 ; Vol. 175, No. 1. pp. 212-219.
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