Pain in chemotherapy-induced peripheral neurotoxicity

Paola Marmiroli, Arianna Scuteri, David Cornblath, Guido Cavaletti

Research output: Contribution to journalArticle

Abstract

Chemotherapy-induced peripheral neurotoxicity (CIPN) is a potentially dose-limiting side effect of the treatment of several cancers. CIPN is predominantly or exclusively sensory, and it is frequently associated with unpleasant symptoms, overall referred to as "pain." However, given the markedly different clinical presentation and course of CIPN depending on the antineoplastic drug used, the broad term "pain" in the specific context of CIPN needs to be reconsidered and refined. In fact, a precise identification of the features of CIPN has relevant implication in the design of rational-based clinical trials and in the selection of possible active drugs.

Original languageEnglish (US)
JournalJournal of the Peripheral Nervous System
DOIs
StateAccepted/In press - 2017

Keywords

  • Chemotherapy
  • Clinical trial
  • Neurotoxicity
  • Pain

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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