Paf15 expression correlates with rectal cancer prognosis, cell proliferation and radiation response

Rong Yan, Kun Zhu, Chengxue Dang, Ke Lan, Haonan Wang, Dawei Yuan, Wei Chen, Stephen J. Meltzer, Kang Li

Research output: Contribution to journalArticle

Abstract

Paf15, which participates in DNA repair, is overexpressed in numerous solid tumors. Blocking of Paf15 inhibits the growth of many types of cancer cells; while simultaneously enhancing cellular sensitivity to UV radiation. However, its expression and function in rectal cancer (RC) remain unknown. The current study was undertaken to assess the association of Paf15 expression with RC prognosis, as well as to explore the participation of Paf15 in the response of RC cells to irradiation. Increased Paf15 expression was observed in RC tissues and associated with pTNM stage and poor survival. In vitro, Paf15 induced increased RC cell proliferation while accelerating cell cycle progression, inhibiting cell death, and protecting against gamma radiationinduced DNA damage in RC cells. In conclusion, increased Paf15 expression is associated with increased RC proliferation, decreased patient survival, and a worse radiotherapeutic response.

Original languageEnglish (US)
Pages (from-to)38750-38761
Number of pages12
JournalOncotarget
Volume7
Issue number25
DOIs
StatePublished - Jan 1 2016

Keywords

  • Cell cycle
  • Gamma radiation
  • Paf15
  • Prognostic factor
  • Rectal cancer

ASJC Scopus subject areas

  • Oncology

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