p63 transcriptional regulation of epithelial integrity and cancer

Barry Trink, Motonobu Osada, Edward Ratovitski, David Sidransky

Research output: Contribution to journalReview article

Abstract

p63 plays a more complex role than initially thought in cancer and development. As a p53 homolog, p63 encodes transcription factors that primarily functions through regulation of downstream gene expression. However, p63 is also involved in RNA processing and activation of β-catenin signaling. A number of genes activated by TAp63 support the notion that p63 is involved in tight transcriptional control of epithelial differentiation, cell adhesion, and tumorigenesis via cell cycle arrest, apoptosis, and other cellualr functions. In addition, ΔNp63 isotypes retain a rather short transactivation domain and were found to transcriptionally regulate a specific set of downstream gene targets. We found that p63 is capable of activating gene expression through binding to specific cis-elements, RE1 and RE2, with the latter being more specific for p63 than for p53. Differences in p53 family members DNA binding may help to explain key differences in their function and biology.

Original languageEnglish (US)
Pages (from-to)240-245
Number of pages6
JournalCell Cycle
Volume6
Issue number3
DOIs
StatePublished - Feb 1 2007

Keywords

  • Cancer
  • Downstream targets
  • Transcription
  • p53
  • p63
  • p73

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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